Fig. 5

miR-503-5p targets and mediates FOXK1 expression. A The predicted complementary binding site of miR-503-5p and FOXK1. B The luciferase activity in OC cells was determined by dual luciferase reporter assay. ***P < 0.001 vs. the miR-NC group. C The expression of FOXK1 in OC tissues (n = 50) and normal tissues (n = 50) was detected by qRT-PCR. ***P < 0.001 vs. the normal group. D-E The correlation between the expression miR-503-5p and FOXK1 and E PART1 and FOXK1 in OC tissues was assessed by Pearson’s correlation analysis. P < 0.0001, R² = 0.6138. F The protein level of FOXK1 in OC cells after transfection of miR-503-5p mimics/miR-NC or sh-PART1–2/NC (G) was determined by western blot assay. H The expression of FOXK1 in SK-OV-3 cells transfected with sh-PART1–2/NC was detected by qRT-PCR. **P < 0.01 vs. the sh-NC group. I The apoptosis of SK-OV-3 cells transfected with sh-PART1–2/NC was analyzed by flow cytometry. **P < 0.01 vs. the sh-NC group