Table 2 Demographic and clinical characteristics of patients in the study (n = 38,842) and matched (n = 9864) cohorts

Age, years (mean ± SD)

71.48 ± 9.51

64.93 ± 12.21

< 0.0001^*

0.599

71.41 ± 9.50

71.93 ± 9.55

0.065

0.055

Age

< 0.0001^*

0.0913

 < 65, n (%)

1060 (21.29)

15,191 (44.86)

0.517

1057 (21.43)

989 (20.05)

0.034

 ≥65, n (%)

3919 (78.71)

18,672 (55.14)

0.517

3875 (78.57)

3943 (79.95)

0.034

Sex, n (%)

< 0.0001^*

0.28

 Male

3245 (65.17)

20,536 (60.64)

0.094

3205 (64.98)

3256 (66.02)

0.022

 Female

1734 (34.83)

13,327 (39.36)

0.094

1727 (35.02)

1676 (33.98)

0.022

Income (NTD), n (%)

< 0.0001^*

0.2085

 0 (Dependent)

1036 (20.81)

5841 (17.25)

0.091

1024 (20.76)

1074 (21.78)

0.025

 1–15,840

991 (19.90)

5476 (16.17)

0.097

978 (19.83)

1009 (20.46)

0.016

 15,841–25,000

2226 (44.71)

16,673 (49.24)

0.091

2209 (44.79)

2190 (44.40)

0.008

 ≥25,000

726 (14.58)

5873 (17.34)

0.075

721 (14.62)

659 (13.36)

0.036

Urbanization, n (%)

0.5737

0.5648

 1 (City)

1380 (27.72)

9088 (26.84)

0.020

1367 (27.72)

1354 (27.45)

0.006

 2

2141 (43.00)

14,758 (43.58)

0.012

2120 (42.98)

2124 (43.07)

0.002

 3

912 (18.32)

6193 (18.29)

0.001

906 (18.37)

875 (17.74)

0.016

 4 (Village)

546 (10.97)

3824 (11.29)

0.010

539 (10.93)

579 (11.74)

0..026

CCI, n (%)

< 0.0001^*

0.3988

 ≤6

2994 (60.13)

17,441 (51.50)

0.174

2955 (59.91)

2996 (60.75)

0.017

 > 6

1985 (39.87)

16,422 (48.50)

0.174

1977 (40.09)

1936 (39.25)

0.017

 Acute myocardial infarction

339 (6.81)

314 (0.93)

< 0.0001^*

0.309

295 (5.98)

249 (5.05)

0.0425

0.041

 Ischemic cerebrovascular accident

138 (2.77)

488 (1.44)

< 0.0001^*

0.903

134 (2.72)

127 (2.58)

0.6606

0.009

 Chronic kidney disease

293 (5.88)

932 (2.75)

< 0.0001^*

0.155

285 (5.78)

274 (5.56)

0.6319

0.010

 Diabetes mellitus

1851 (37.18)

6507 (19.22)

< 0.0001^*

0.407

1825 (37.00)

1802 (36.54)

0.6310

0.010

 Hypertension

3954 (79.41)

15,041 (44.42)

< 0.0001*

0.773

3907 (79.22)

3979 (80.68)

0.0702

0.036

 Dyslipidemia

2289 (45.97)

7666 (22.64)

< 0.0001^*

0.507

2248 (45.58)

2170 (44.00)

0.1143

0.032

 Atrial fibrillation

380 (7.63)

696 (2.06)

< 0.0001*

0.262

372 (7.54)

335 (6.79)

0.1487

0.029

 GI bleeding

228 (4.58)

1067 (3.15)

< 0.0001*

0.074

225 (4.56)

211 (4.28)

0.4928

0.014

 Chemotherapy

4057 (81.48)

28,723 (84.82)

< 0.0001^*

0.089

4027 (81.65)

4033 (81.77)

0.8758

 Erlotinib

720 (14.46)

4637 (13.69)

0.1426

0.022

713 (14.46)

646 (13.10)

0.0503

0.039

 Gefitinib

1034 (20.77)

6351 (18.75)

0.0007^*

0.051

1018 (20.64)

943 (19.12)

0.0585

0.038

 Radiotherapy

2575 (51.72)

18,446 (54.47)

0.0003^*

0.055

2554 (51.78)

2539 (51.48)

0.7625

0.006