Fig. 2

Temozolomide sensitivity measured by half-maximal inhibitory concentration (IC₅₀) in different cell lines stratified by temozolomide exposure time. (A) IC₅₀ summarised for cell lines that had at least 10 measurements reported in the included studies at the specified exposure time. Tests for homogeneity of variances showed no evidence of a difference between cell lines at 72 h (Levene’s test: p = 0.249; Fligner-Killeen test: p = 0.389). References for these studies are: U87 at 24 h,^{s9 s21 s26 s56 s57 s60 s83 s91 s105 s120 s146 s209} U87 at 48 h,^{s31 s58 s67 s88 s96 s109 s112 s114 s121 s156 s160 s163 s189 s197 s205 s209 s211} U251 at 48 h,^{s17 s44 s29 s31 s58 s67 s88 s96 s99 s109 s112 s114 s116 s149 s152 s156 s175 s184 s186 s187 s189 s197 s211} U87 at 72 h,^{s7 s13 s14 s48 s50 s63 s94 s97 s98 s104 s106 s128 s130 s134 s135 s137 s138 s145 s154 s158 s166 s169 s174 s195 s196 s198 s200 s203 s212} U251 at 72 h,^{s2 s30 s37 s46 s59 s97 s125 s131 s134 s135 s145 s154 s166 s167 s174 s181 s185 s196 s200 s203 s212} T98G at 72 h,^{s2 s28 s46 s48 s63 s94 s145 s166 s167 s192 s196 s200} and patient-derived cell lines at 72 h.^{s14 s122 s123 s127}. (B) Further restricting to studies that did not use a hypoxic environment and quantified cell viability using MTT. Exposure time in hours is shown on the top panel. IC₅₀ = half-maximal inhibitory concentration. References for these studies are: U251 at 48 h ^{s31 s44 s58 s96 s149 s152 s156 s175 s187 s189} and U87 at 72 h^{s7 s13 s98 s106 s128 s130 s134 s137 s145 s166 s195 s200 s212}