Table 3 Multivariate Cox regression analysis for overall survival (OS) and recurrence free survival (RFS) in 104 HCC patients

Age (≤ 60 vs. >  60 years)

1.528 (0.746–3.130)

0.246

0.848 (0.437–1.645)

0.627

Gender (males vs. females)

1.109 (0.439–2.790)

0.827

1.795 (0.745–4.325)

0.192

Pathological stage (high and/or middle vs. low)

3.411 (1.689–6.888)

< 0.001

2.785 (1.591–4.877)

< 0.001

Tumor diameter (≤ 5 vs. >  5 cm)

0.913 (0.403–2.071)

0.828

1.769 (0.846–3.699)

0.130

AFP (>  400 vs. <  400 ng/ml)

3.346 (1.483–7.550)

0.004

0.911 (0.470–1.764)

0.782

Child-Pugh grade (A vs. B)

2.993 (1.366–6.556)

0.006

1.042 (0.431–2.521)

0.927

Tumor Recurrence (yes vs. no)

4.507 (2.082–9.756)

< 0.001

–

–

CRBP-1 (high vs. low)

0.493 (0.203–1.197)

0.018

0.611 (0.279–1.341)

0.019