Table 3 Univariate and multivariate analysis of prognostic factors for PFS in patients with DLBCL

Age (>60 vs ≤60)

1.282 (0.745–2.204)

0.370

Sex (male vs female)

0.927 (0.552–1.555)

0.773

B symptoms (present vs absent)

1.421 (0.815–2.480)

0.216

LDH (>ULN vs normal)

2.260 (1.329–3.843)

0.003

ECOG score (2-4 vs 0-1)

2.111 (1.228–3.630)

0.007

Ann Arbor Stage (III-IV vs I-II)

2.253 (1.214–4.179)

0.010

Extranodal disease (>1 vs ≤1)

2.063 (1.226–3.472)

0.006

IPI

<0.001

<0.001

 Low risk (0-1)

reference

reference

 Low-intermediate risk (2)

1.592 (0.726–3.490)

0.245

1.592 (0.726–3.490)

0.245

 High-intermediate risk (3)

4.238 (2.127–8.444)

<0.001

4.238 (2.127–8.444)

<0.001

 High risk (4-5)

3.140 (1.406–7.012)

0.005

3.140 (1.406–7.012)

0.005

Subtype (GCB vs non-GCB)

1.151 (0.774–1.711)

0.487

FFAs (high vs normal)

2.050 (1.193–3.525)

0.009