Fig. 8

Evaluation of mutation patterns and immune features between different risk groups. A Overall view of mutation patterns in PAAD patients. B The coexpression patterns of the top 20 mutated genes in PAAD patients. C-D Waterfall plot visualizing the top 30 genes that mutated most frequently in the low-risk and high-risk groups. E The infiltration levels of CD8 T cells, regulatory T cells, and memory CD4 T cells activated between different risk groups. F Correlation analysis between riskScores and CD8 T cells (R = -0.37, P < 0.0001), activated CD4 memory T cells (R = -0.16, P = 0.081), and regulatory T cells (R = -0.27, P = 0.0026). G Correlation analysis between riskScores and CD47 (R = 0.32, P < 0.0001), CD276 (R = 0.34, P < 0.0001), LAG3 (R = -0.11, P = 0.13), PD-L1 (R = 0.31, P < 0.0001), and PVR (R = 0.21, P = 0.0059). H The expression of CD47, CD276, LAG, PD-L1, and PVR between the high- and low-risk groups. PAAD: Pancreatic adenocarcinoma