Fig. 5
From: MicroRNA-1915-3p inhibits cell migration and invasion by targeting SET in non-small-cell lung cancer
SET is a critical mediator of miR-1915-3p effects. A, B miR-1915-3p suppressed migration and invasion of NSCLC cells, and re-expression of SET rescued miR-1915-3p-induced inhibitory effects. Scale bars, 100 μm. C The restoration of SET expression abrogated the miR-1915-3p-mediated inhibition of N-cadherin/Vimentin and induction of E-cadherin. D, E Overexpression of miR-1915-3p alone showed a significant inhibition in JNK/Jun and NF-κB signaling pathway, whereas ectopic expression of SET attenuated these effects