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Table 7 Univariate and multivariate analyses of prognostic factors for OS in patients with UGC

From: Impact of skeletal muscle mass in patients with unresectable gastric cancer who received palliative first-line chemotherapy based on 5-fluorouracil

 

Univariate analysis

Multivariate analysis

 

Hazard ratio

95% CI

P value

Hazard ratio

95% CI

P value

Age (≧75 vs < 75)

1.148

0.680–1.938

0.605

   

Gender (Female vs Male)

1.224

0.718–2.086

0.457

   

ECOG PS (1,2 vs 0)

2.203

1.372–3.537

0.001

1.355

0.786–2.337

0.274

BMI (< 18.0 vs ≧18.0)

1.401

0.864–2.271

0.172

   

SMI (Low vs High)

1.964

1.183–3.252

0.009

1.886

1.156–3.077

0.011

Histologic type (Differentiated vs Undifferentiated)

1.775

1.087–2.897

0.022

1.619

0.990–2.648

0.061

Peritoneum metastasis (Present vs Absent)

1.138

0.698–1.854

0.605

   

Lymph node metastasis (Present vs Absent)

1.019

0.642–1.618

0.936

   

Hematogenous metastasis (Present vs Absent)

1.101

0.675–1.793

0.702

   

Lines of chemotherapy (≧2nd line vs < 2nd line)

0.958

0.513–1.789

0.893

   

Lines of chemotherapy (≧3rd line vs <3rd line)

0.408

0.253–0.659

< 0.001

0.420

0.248–0.712

< 0.001

PNI (<  43.9 vs ≧43.9)

1.589

0.991–2.813

0.052

   

NLR (≧2.881 vs < 2.881)

2.071

1.297–3.307

0.002

2.167

1.325–3.544

0.002

CAR (≧0.077 vs < 0.077)

1.361

0.854–2.171

0.195

   

PLR (≧267 vs < 267)

1.490

0.885–2.510

0.134

   
  1. BMI, body mass index; CAR, C-reactive protein-to-albumin ratio; ECOG PS, Eastern Cooperative Oncology Group performance status; NLR, neutrophil to lymphocyte ratio; OS, overall survival; PLR, platelet to lymphocyte ratio; PNI, the prognostic nutritional index; SMI, skeletal musclemass; UGC, unresectable gastric cancer