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Table 4 Univariate and multivariate analyses for survival outcomes in patients with high-risk factors

From: Survival impact of additional chemotherapy after adjuvant concurrent chemoradiation in patients with early cervical cancer who underwent radical hysterectomy

Characteristics

 

(A) Disease-free survival

(B) Overall survival

Univariate analysis

Multivariate analysis

Univariate analysis

Multivariate analysis

HR

95% CI

P

aHR

95% CI

P

HR

95% CI

P

aHR

95% CI

P

Histology

Non-SCC vs. SCC

2.040

0.932–4.464

0.074

2.230

0.961–5.175

0.062

1.658

0.453–6.060

0.445

1.246

0.321–4.827

0.751

2009 FIGO stage

IIA vs. IB

0.800

0.356–1.797

0.588

   

1.903

0.637–5.684

0.249

   

Para-aortic lymphadenectomy

Yes vs. No

0.934

0.437–1.995

0.860

   

1.559

0.523–4.642

0.426

   

Pathologic cervical tumor size*

≥40 vs. < 40 mm

1.368

0.651–2.874

0.409

1.514

0.692–3.309

0.299

1.716

0.528–5.578

0.369

1.289

0.368–4.515

0.691

Parametrial invasion

Yes vs. No

1.367

0.658–2.838

0.402

2.348

1.047–5.264

0.038

4.896

1.085–22.094

0.039

9.662

1.841–50.712

0.007

Lymph node metastasis

Yes vs. No

3.077

0.933–10.150

0.065

5.198

1.450–18.635

0.011

4.122

0.536–31.725

0.174

10.198

1.160–89.675

0.036

Surgical approach

MIS vs. Open surgery

2.072

1.011–4.247

0.047

3.406

1.558–7.448

0.002

1.030

0.312–3.400

0.961

3.029

0.775–11.833

0.111

Additional chemotherapy

Yes vs. No

1.193

0.579–2.456

0.632

1.138

0.529–2.448

0.742

2.062

0.671–6.335

0.206

2.065

0.622–6.857

0.236

  1. Abbreviations: CCRT concurrent chemoradiation therapy; FIGO International Federation of Gynecology and Obstetrics. *Measured from the uterine specimen