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Fig. 5 | BMC Cancer

Fig. 5

From: Protein deubiquitylase USP3 stabilizes Aurora A to promote proliferation and metastasis of esophageal squamous cell carcinoma

Fig. 5

USP3 interacts with Aurora-A to inhibit ubiquitination of Aurora A K143. A Aurora A ubiquitinated mutant Aurora A K143R was constructed and expressed in ECa109 cells. B-C Exogenous overexpression of Flag-USP3 and HA-Aurora A, co-IP experiments demonstrated the interaction. D-E Endogenous co-IP demonstrates the interaction between USP3 and Aurora A. F After the mutation Aurora A K143 was to K143R, the interaction between USP3 and Aurora A was reduced. G The ubiquitination of Aurora A was detected after overexpression of USP3. H Compare the ubiquitination levels of Aurora A K143R and Aurora A

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BMC Cancer

ISSN: 1471-2407

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