Fig. 4
Association of Foxp3+ T cells in the PDAC TME with clinical prognosis. Quantitative scoring of the Foxp3+ T cells surrounding 10 random tumor areas in PDAC samples was performed. The average counts of cells/mm2 tumor area were graded as low density (≤ median cell counts/mm2 tumor area) or high density (> median cell counts/mm2 tumor area) (A). Samples were classified into 2 subgroups based on Foxp3+ T cell density: high and low Foxp3+ cell density. The Kaplan-Meier estimates of the OS (left panel) and DFS (right panel) times of the 2 subgroups are shown (B). PDAC patients with high CD3+ T cell density were classified into 2 subgroups: high CD3+/high Foxp3+ T cell density and high CD3+/low Foxp3+ T cell density. The Kaplan-Meier estimates of the OS (left panel) and DFS (right panel) times of the 2 subgroups are shown (C). Foxp3: forkhead box P3; PDAC: pancreatic ductal adenocarcinoma; OS: overall survival; DFS: disease-free survival