Can addition of frozen section analysis to preoperative endometrial biopsy and MRI improve identification of high-risk endometrial cancer patients?

Table 2 Diagnostic performance of preoperative examination (pre-op EB and/or MRI) versus frozen section for grade, stage, and risk level

High-grade tumor	Sensitivity	Specificity	PPV	NPV	Accuracy	P value
pre-op EB	59.6	98.4	93.3	86.6	87.8	0.44
Frozen sections	55.3	99.2	96.3	85.5	87.2	0.44
P value	0.56	0.56
High-stage tumor
MRI	74.4	83.0	59.3	90.7	80.8	<0.001
FS	46.5	99.2	95.2	83.4	86.0	<0.001
P value	0.003	<0.001
High-risk patient
MRI + pre-op EB	78.3	85.4	78.3	85.4	82.6	<0.001
FS	55.1	99	97.4	76.7	81.2	<0.001
P value	<0.001	<0.001
MRI + pre-op EB + FS	81.2	85.4	78.9	87.1	83.7	<0.16^a
P value	0.16^a	> 0.99^a

ISSN: 1471-2407