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Table 2 Diagnostic performance of preoperative examination (pre-op EB and/or MRI) versus frozen section for grade, stage, and risk level

From: Can addition of frozen section analysis to preoperative endometrial biopsy and MRI improve identification of high-risk endometrial cancer patients?

High-grade tumor Sensitivity Specificity PPV NPV Accuracy P value
pre-op EB 59.6 98.4 93.3 86.6 87.8 0.44
Frozen sections 55.3 99.2 96.3 85.5 87.2
P value 0.56 0.56  
High-stage tumor
 MRI 74.4 83.0 59.3 90.7 80.8 <0.001
 FS 46.5 99.2 95.2 83.4 86.0
P value 0.003 <0.001  
High-risk patient
 MRI + pre-op EB 78.3 85.4 78.3 85.4 82.6 <0.001
 FS 55.1 99 97.4 76.7 81.2
P value <0.001 <0.001  
 MRI + pre-op EB + FS 81.2 85.4 78.9 87.1 83.7 <0.16a
P value 0.16a > 0.99a  
  1. pre-op EB preoperative endometrial biopsy
  2. FS frozen section
  3. McNemar’s test was used for statistical analyses
  4. aVersus MRI + pre-op EB