Can addition of frozen section analysis to preoperative endometrial biopsy and MRI improve identification of high-risk endometrial cancer patients?

Table 1 Characteristics of low-risk and high-risk patients

	Low-risk patients	High-risk patients	P value
N	103	69
Age (y)	54.3 ± 9.53	59.8 ± 11.0	P < 0.001^b
Histologic subtype	No lesion 2	G1 18
	APAM 2	G2 4
	AEH 5	G3 23
	G1 71	CL 4
	G2 23	S 12
		CS 6
		Others 2
T factor (TNM classification)	T1a without myometrial invasion 23	T1a without myometrial invasion 3
	T1a 80	T1a 22
		T1b 22
		T2 3
		T3a 12
		T3b 7
Lymph node metastasis	0	13	P < 0.001^a
CA125 (U/ml)	37.7 ± 116.5	139.2 ± 414.5	P < 0.001^b
CEA (ng/ml)	4.35 ± 26.4	5.16 ± 15.0	0.02^b
CA19–9 (U/ml)	55.1 ± 230.3	104.2 ± 255.3	0.74^b

APAM atypical polypoid adenomyoma
AEH atypical endometrial hyperplasia
G1, G2, G3 endometrioid adenocarcinoma grade 1, 2, 3
CL clear cell carcinoma
S serous carcinoma
CS carcinosarcoma
TNM classification: The 8th edition of the Union for International Cancer Control (UICC)-Tumor Node Metastasis (TNM) classification
^a: Fisher’s exact test
^b: Wilcoxon rank-sum test

ISSN: 1471-2407