Table 1 Summary of publications reporting on the prognostic impact of F. nucleatum in oral cancers
From: Fusobacterium nucleatum and oral cancer: a critical review
Author | Reference | Specimen type | Detection method | Number of cases | F. nucleatum detection rate | Prognostic impact of F. nucleatum detection | Molecular and clinicopathological associations with tumour F. nucleatum positivity |
|---|---|---|---|---|---|---|---|
Neuzillet et al (2021) | 66 | Fresh frozen OSCC | qPCR | 151 | 82.1% Fn-positive (124/151) | Better OS, RFS and MFS | Older (> 56 years), non-drinkers, low pN stage. Low RNA levels of M2 macrophages (CD163), CD4 lymphocytes, fibroblasts (PDGFRß), TLR4, OX40 ligand (TNFSF4) High levels of TNFSF9 and IL-1ß |
Chen et al (2020) | 67 | Fresh frozen HNSCC | qPCR | 68 | 55.8% Fn-high (38/68) | Better CSS and RFS | Non-smokers, lower tumour stage, hypermethylation of LXN and SMARCA2 genes |