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Table 2 Treatment characteristics

From: Relevance of the time interval between surgery and adjuvant radio (chemo) therapy in HPV-negative and advanced head and neck carcinoma of unknown primary (CUP)

 

All patients (n = 59)

Early treatment group (n = 30)

Delayed treatment group (n = 29)

Statistical comparison

Time span

 Neck Dissection – Adjuvant Therapy (mean d ± SD)

57.45 ± 21.75

41.69 ± 9.03

73.21 ± 19.16

t(56) = 8.01, p < 0.001

Surgical treatment modality (n, %)

 Selective Neck Dissection

33 (55.9%)

19 (63.3%)

14 (48.3%)

 

 Modified Radical Neck Dissection

10 (17.0%)

5 (16.7%)

5 (17.2%)

X2(2) = 1.74, p = 0.419

 Radical Neck Dissection

16 (27.12%)

6 (20.0%)

10 (34.5%)

 

Adjuvant treatment modality (n, %)

 Radiation therapy

4 (6.8%)

2 (6.7%)

2 (6.9%)

Fisher’s Z: p > 0.999

 Chemoradiation therapy

55 (93.2%)

28 (93.3%)

27 (93.1%)

 

Radiation dose in Gy (mean ± SD)

69.84 ± 8.19

70.41 ± 8.88

69.25 ± 7.54

Z = 0.49, p = 0.621

Chemotherapy (n, %)

 Cisplatin/ Carboplatin+ 5-FU

31 (56.4%)

17 (60.7%)

14 (51.8%)

X2(1) = 0.44, p = 0.508

 Other

24 (43.6%)

11 (39.3%)

13 (48.2%)

 

Number of removed lymph nodes

21.95 ± 10.70

21.30 ± 10.96

22.62 ± 10.61

t(57) = 0.47, p = 0.639

Lymph Node Ratio (LNR; mean ± SD)

0.25 ± 0.43

0.31 ± 0.57

0.18 ± 0.21

Z = 1.11, p = 0.268

  1. Abbreviations: Early treatment group = adjuvant treatment was implemented in less than 55 d after surgery; Delayed treatment group = adjuvant treatment was implemented within or later than 55 d following surgery; SD standard deviation; Gy Gray; 5-FU 5-Fluorouracil