High regional mortality due to malignant melanoma in Eastern Finland may be explained by the increase in aggressive melanoma types

Table 3 The association of melanoma parameters with metastasis

	*Metastasis into lymph nodes or distal organs*		*p-value within subgroup*
	n	*% within subgroup*	*p-value within subgroup*
CMM subtype
NM	52/120	43.3%	< 0.001
ALM	10/29	34.5%
SSM	11/114	9.6%
LM/LMM	0/74	0.0%
Clark
5	21/28	75.0%	< 0.001
4	28/70	40.0%
3	17/83	20.5%
2	5/44	11.4%
1	2/112	1.8%
Breslow
4	27/42	64.3%	< 0.001
3	22/47	46.8%
2	12/46	26.1%
1	12/202	5.9%
Ulceration
Yes	27/51	52.9%	< 0.001
No	46/286	16.1%	< 0.001
Mitosis Count
A lot	35/83	42.2%	< 0.001
Little	20/113	17.7%
No Mitosis	2/28	7.1%
LV/BV/PN
Yes	2/3	66.7%	< 0.001
No	7/100	7.0%	< 0.001
Microsatellites
Yes	7/12	58.3%	0.044
No	4/18	22.2%	0.044
Body site
Foot & sole	8/21	38.1%	0.022
Genitalia/perianal area	1/3	33.3%
Trunk	33/113	29.2%
Palm	2/8	25.0%
Lower limb	7/29	24.1%
Upper limb	6/41	14.6%
Head & neck	15/120	12.5%
Total	73/337	21.7%

NM = nodular; ALM = acral lentiginous; SSM = superficial spreading; and LM/LMM = lentigo maligna/lentigo maligna melanoma; LV/BV/PN = invasion into lymphatic/blood vessels or perineural area

ISSN: 1471-2407