Fig. 3

EBV and HPV infections showed decreased genomic variations. A Genomic features of EBV-infection, HBV-infection and HPV-infection in STAD, LIHC and HNSC, respectively. Comparisons were made between infected and non-infected tumor samples for each cancer type. Significant results are labeled (*:0.05–0.01; **:0.01–0.001; ***:0.001–0.0001; ****: < 0.0001; two-tailed Mann-Whitney U test). B Genomic features of viral infections. We analyzed EBV-infected STAD, CMV-infected STAD, HBV-infected LIHC and HPV-infected HNSC. All genomic features are significantly decreased in HPV-infected HNSC, four features are significantly decreased in EBV-infected STAD. By comparison, five features are significantly increased in HBV-infected LIHC. No significant change were found in CMV-infected STAD (p < 0.05; two-tailed Mann-Whitney U test). C Comparison between tumors with different viral infections and MSI (microsatellite instability)-high tumors. The red, green and blue dots represent for TMB-high, TMB-intermediate and TMB-low, respectively. D Correlation between TMB burden and HPV-infection. TMB levels showed significant negative correlation with RNA expressions in all HPV-infected tumors (R = -0.348, p < 0.05, Spearman’s rank correlation)