Table 1 Key Inclusion and Exclusion Criteria

Inclusion criteria

1. Age ≥ 20 years, < 75 years

2. Written informed consent

3. Histologically or cytologically confirmed NSCLC

4. Activating driver mutation negative or unknown: epidermal growth factor receptor (EGFR), anaplastic lymphoma kinase (ALK), proto-oncogene 1 (ROS1), BRAF and MET^a

5. No previous chemotherapy

6. Synchronous oligo-metastatic stage IV disease: maximum of three distant metastases^b

7. Suitable candidate for LAT (radiotherapy and/or surgery) to all site of disease, as determined by a multidisciplinary tumour board

8. Eastern Cooperative Oncology Group (ECOG) performance status score of 0 or 1

9. No malignant dissemination, pericardial effusion, leptomeningeal metastases, peritoneal dissemination and ascites

10. Adequate hematologic and organ function

Exclusion criteria

1. Presence of any other active cancer

2. Presence of active infections requiring antibiotics

3. History of active autoimmune disease requiring systemic treatment

4. History of interstitial lung disease diagnosed or severe chronic obstructive pulmonary disease (COPD)