Clinical details | Molecular Genetics | Leukemia-associated immunophenotype (LAIP) | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
BBa | Response | Karyotype | Gene | Mutation | Amino acid change | Variant allele frequency | LAIP details | Pre-C % | Post-C % | |
Pre-C % | Post-C % | |||||||||
64 | Borderline refractory with persistent inv.(3) | Inv(3) | KRAS GATA2 PTEN NOTCH1 | Missense Missense Missense Missense | G13D L321V G251D D2108N | 49 40 0 0 | 26 27 12 22 | CD34hi/CD13+ | 10.4 | 24.4 |
121 | Refractory | Inv(3) | PTPN11 | Missense | G503A | 45 | 50 | CD34+/CD33+/−/HLADRwk/−CD34hi/CD13+ | 57.1 20.6 | 21.7 50.4 |
205 | Refractory | Monosomal | PTPN11 DNMT3A | Missense Missense | E76Q A192G | 24 16 | Failed | CD34hi/CD33+ CD34+/CD33+/HLADRwk | 70.9 25.0 | 5.12 30.9 |
285 | Refractory | Normal | FLT3 TET2 KIT U2AF1 EZH2 TET2 TP53 WT1 | Missense Stop-gain Missense Missense Frameshift Missense Missense Missense | D835E R1452X P623L S34F N/A D1242G E307G R401K | 47 41 11 0 0 0 0 0 | 31 35 0 26 41 20 16 12 | CD34+/CD33+/−/CD7+ | 57.2 | 90.3 |
349 | Refractory | Normal | IDH2 TET2 | Missense Stop-gain | R172K Q1539X | 60 0 | 57 12 | CD117hi | 9.11 | 5.98 |
494 | Refractory | Monosomal | TP53 JAK2 FBXW7 | Missense Missense Missense | R234H N533D E471K | 94 12 11 | 99 0 0 | CD117+/CD45hi CD117+/CD33+/CD7+ | 32.2 34.4 | 34.2 34.2 |