Identification and characterization of a 25-lncRNA prognostic signature for early recurrence in hepatocellular carcinoma

Table 2 Univariate and multivariate Cox analysis of risk factors in the TCGA entire group (N = 299)

Characteristics	Univariate			Multivariate
Characteristics	Hazard Ratio	CI 95	P Value	Hazard Ratio	CI 95	P Value
1-year DFS
risk score of 25-lncRNA signature	2.38	1.88–3.01	< 0.001	2	1.48–2.71	< 0.001
TNM Stages	1.96	1.55–2.47	< 0.001	1.28	0.94–1.75	0.124
Vascular Invasion	1.88	1.35–2.61	< 0.001	1.66	1.12–2.45	0.011
AFP	2.52	1.56–4.07	< 0.001	2.23	1.34–3.74	0.002
Cirrhosis	1.11	0.65–1.9	0.709
Gender	1.17	0.78–1.77	0.444
Age	0.77	0.49–1.22	0.269
Race	1.15	0.83–1.59	0.396
2-year DFS
risk score of 25-lncRNA signature	2.19	1.8–2.66	< 0.001	1.92	1.48–2.49	< 0.001
TNM Stages	1.96	1.61–2.39	< 0.001	1.46	1.12–1.89	0.005
Vascular Invasion	1.8	1.36–2.38	< 0.001	1.5	1.05–2.12	0.024
AFP	2.03	1.37–2.99	< 0.001	1.77	1.16–2.71	0.008
Cirrhosis	1.25	0.81–1.93	0.305
Gender	1.21	0.86–1.71	0.27
Age	0.91	0.6–1.36	0.635
Race	0.84	0.62–1.12	0.229

In univariate and multivariate Cox analysis, risk score, TNM stages and vascular invasion were evaluated as continuous variables, and AFP, cirrhosis, gender, age and race were evaluated as category variables. Age category and AFP category were defined by 50 and 20 ng/ml as cut-off value, respectively

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