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Table 2 Univariate and multivariate Cox analysis of risk factors in the TCGA entire group (N = 299)

From: Identification and characterization of a 25-lncRNA prognostic signature for early recurrence in hepatocellular carcinoma

Characteristics Univariate Multivariate
Hazard Ratio CI 95 P Value Hazard Ratio CI 95 P Value
1-year DFS
 risk score of 25-lncRNA signature 2.38 1.88–3.01 < 0.001 2 1.48–2.71 < 0.001
 TNM Stages 1.96 1.55–2.47 < 0.001 1.28 0.94–1.75 0.124
 Vascular Invasion 1.88 1.35–2.61 < 0.001 1.66 1.12–2.45 0.011
 AFP 2.52 1.56–4.07 < 0.001 2.23 1.34–3.74 0.002
 Cirrhosis 1.11 0.65–1.9 0.709    
 Gender 1.17 0.78–1.77 0.444    
 Age 0.77 0.49–1.22 0.269    
 Race 1.15 0.83–1.59 0.396    
2-year DFS
 risk score of 25-lncRNA signature 2.19 1.8–2.66 < 0.001 1.92 1.48–2.49 < 0.001
 TNM Stages 1.96 1.61–2.39 < 0.001 1.46 1.12–1.89 0.005
 Vascular Invasion 1.8 1.36–2.38 < 0.001 1.5 1.05–2.12 0.024
 AFP 2.03 1.37–2.99 < 0.001 1.77 1.16–2.71 0.008
 Cirrhosis 1.25 0.81–1.93 0.305    
 Gender 1.21 0.86–1.71 0.27    
 Age 0.91 0.6–1.36 0.635    
 Race 0.84 0.62–1.12 0.229    
  1. In univariate and multivariate Cox analysis, risk score, TNM stages and vascular invasion were evaluated as continuous variables, and AFP, cirrhosis, gender, age and race were evaluated as category variables. Age category and AFP category were defined by 50 and 20 ng/ml as cut-off value, respectively