Fig. 3

GO terms and KEGG pathway analysis results for hub genes. (A) Bubble plot of biological process (BP), cellular component (CC), and molecular function (MF) GO terms of hub genes. (B) Bubble plot for the KEGG pathway analysis of hub genes. GO term or pathway description was assigned to the y axis and gene ratio, as the proportion of differential genes in the whole gene set, was assigned to x axis. The bubble size represents the gene count of the corresponding GO term or pathway. (C) KEGG chord plot showing the relationship between enrichment pathways and genes, with chords linking each protein to the functions/processes it is related to. A gene is linked to a certain pathway by a colored chord, and blue-to-red coding next to the genes indicates logFC. (D) KEGG cluster of genes grouped by their functional categories. The inner ring shows the color-coded logFC, and the outer ring shows the assigned signaling pathways