Skip to main content
Fig. 1 | BMC Cancer

Fig. 1

From: The detection of specific hypermethylated WIF1 and NPY genes in circulating DNA by crystal digital PCR™ is a powerful new tool for colorectal cancer diagnosis and screening

Fig. 1

Genomic environment of the dPCR target associated with WIF1 and NPY. A) WIF1 is located on the reverse strand of the 12th chromosome’s long arm (12q14.3). The 5′ region of WIF1 is covered by a 1 kb wide CpG island that contains 84 CpG. Within this CpG island is the 67 bases wide dPCR target that contains 5 CpG. The target is entirely contained within the 5’UTR of WIF1 and does not overlap the promoter of WIF1 (chr12: 65,121,532-65,121,731) (Encode: EH38E16200601). B) NPY is located on the short arm of the 7th chromosome (7p15.3). The 5′ region of NPY is covered by a 1,6 kb wide CpG island that contains 123 CpG. Within this CpG island is the 96 bases wide dPCR target that contains 11 CpG. It partially overlaps with the 5’UTR of NPY and is entirely contained within the promoter of NPY (chr7: 24,283,952-24,284,290) (Encode: EH2540595). Illustration not to scale for clarity.

Back to article page

BMC Cancer

ISSN: 1471-2407

Contact us