Fig. 1

miR-17-5p is increased in HNSCC tissues and cell lines. (A) qRT-PCR was used to detected miR-17-5p expression level in HNSCC tissues (n = 64) and non-tumor tissues (n = 18). Normalized to U6. *p < 0.01 vs. normal tissues. (B) Multivariable risk factor and 95% confidence interval for HNSCC. Lymph node metastasis (HR = 25.049) and miR-17-5p (HR = 6.071) were independent risk factors for HNSCC patients (P < 0.05). (C) Log-rank (Mantel-Cox) test for the non-recurrence rate of HNSCC patients with low or high level of miR-17-5p. P = 0.0023. (D) The diagnostic potential of miR-17-5p in HNSCC patients. The area under the ROC curve was 0.7253 (95% CI: 0.5991 to 0.8516; p < 0.0001). (E) qRT-PCR was used to detect miR-17-5p expression level in four HNSCC cell lines (AMC-HN8, Tu686, FaDu, and Detriot562) compared with human posterior commissure of the larynx cell line HuLa-PC