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Table 1 The distributions of specific characteristics by cases and controls status

From: Combined effects of cigarette smoking, DNA methyltransferase 3B genetic polymorphism, and DNA damage on lung cancer

Variables

Cases

Controls

 
 

N = 190 (%)

N = 380 (%)

OR (95% CI)a

Gender

 Male

115 (60.5%)

230 (60.5%)

1.00 (0.84–1.20)

 Female

75 (39.5%)

150 (39.5%)

Ref.

Age (years; mean ± SD)

65.5 ± 11.9

64.4 ± 11.8

 

  ≥ 60

132 (69.5%)

252 (66.3%)

1.02 (1.01–1.04)**

 51–59

38 (20.0%)

88 (23.2%)

0.93 (0.78–1.11)

  ≤ 50

20 (10.5%)

40 (10.5%)

Ref.

Smoking status

 Current or ever smokers

102 (53.7%)

118 (31.1%)

2.20 (1.84–2.63)***

 Nonsmokers

88 (46.3%)

262 (68.9%)

Ref.

Pack-years smoked

  ≥ 40

65 (34.2%)

60 (15.8%)

2.46 (2.43–2.50)***

 1–39

37 (19.5%)

58 (15.3%)

1.90 (1.59–2.28)***

 0

88 (46.3%)

262 (68.9%)

Ref.

Green tea consumption (cup/day)

 0

146 (76.8%)

250 (65.8%)

1.71 (1.68–1.73)***

  < 1

29 (15.3%)

54 (14.2%)

1.65 (1.38–1.98)**

  ≥ 1

15 (7.9%)

76 (20.0%)

Ref.

Green tea consumption (years)

 0

146 (76.8%)

250 (65.8%)

1.32 (1.30–1.34)*

  ≤ 10

23 (12.1%)

67 (17.6%)

1.02 (0.86–1.23)

  >  10

21 (11.1%)

63 (16.6%)

Ref.

Fruits and vegetables intake

  ≤ 14

48 (25.3%)

139 (36.6%)

0.80 (0.78–0.81)*

 15–20

51 (26.8%)

69 (18.2%)

1.18 (0.99–1.41)

  ≥ 21

91 (47.9%)

172 (45.2%)

Ref.

Exposure to cooking fumes (hours/week)

  ≥ 3

17 (8.9%)

16 (4.2%)

1.64 (1.61–1.66)***

 1–3

19 (10.0%)

15 (4.0%)

1.85 (1.55–2.21)***

  < 1

154 (81.1%)

349 (91.8%)

Ref.

Family history of lung cancer

 Yes

15 (7.9%)

6 (1.6%)

2.38 (1.99–2.84)***

 No

175 (92.1%)

374 (98.4%)

Ref.

DNMT3B − 149 genotypes

 TT

183 (96.3%)

345 (90.8%)

1.62 (1.35–1.94)*

 CT

7 (3.7%)

35 (9.2%)

Ref.

 CC

0 (0.0%)

0 (0.0%)

 

 T allele

373 (98.2%)

725 (95.4%)

1.63 (1.21–2.18)*

 C allele

7 (1.8%)

35 (4.6%)

Ref.

Histological type

 Adenocarcinoma

108 (56.8%)

  

 Squamous cell carcinoma

51 (26.9%)

  

 Othersb

31 (16.3%)

  
  1. Abbreviation: N number; OR odds ratio; CI confidence interval; Ref. reference
  2. aData were matched by age and gender
  3. bOthers included small cell carcinoma, large cell carcinoma, mixed cell carcinoma, and unspecific malignant cell
  4. *0.01 < p < 0.05, **0.001 < p < 0.01, ***p < 0.001