Fig. 5
From: Co-expression of YAP and TAZ associates with chromosomal instability in human cholangiocarcinoma
Nuclear YAP enrichment and activity associate with the CIN marker pH2AX and poor clinical outcome. A Examples for YAP, TAZ and pH2AX positivity in human iCCA and dCCA cohorts. Bars: 50 μm. B Heatmap summarizing the expression of all CIN25 gene signature genes in an iCCA patient cohort. Expression data was divided into 3 groups by using the k-mean clustering algorithm (normal, cluster 1 and cluster 2). C Distribution of CIN25 gene signature is illustrated by the CIN gene score in normal bile duct tissue (Normal), Cluster 1 (low CIN gene signature score) and Cluster 2 (high CIN gene signature score). D Differences in overall survival of iCCA patients after median clustering of patients based on high or low relative expression of the CIN25 signature. Statistical test: Log-rank (Mantel-Cox)