Table 3 Comparison of resistance indicator candidates for six anticancer drugs in SNU-228 cells

IC50

Control

10.2

> 20

7.02

> 10

19.45

19.72

Resistant cells

11.76 (1.15)

6.33 (< 0.32)

9.22 (1.31)

2.38 (< 0.24)

11.03 (0.57)

12.21 (0.62)

Reversible

10.04 (0.98)

15.67 (< 0.78)

9.62 (1.37)

2.95 (< 0.30)

9.3 (0.48)

10.63 (0.54)

GI50

Control

2.88

1.74

1.57

1.8

0.08

0.01

Resistant cells

4.65 (1.61)

3.31 (1.90)

3.54 (2.25)

1.86 (1.03)

0.001 (0.01)

0.003 (0.30)

Reversible

5.08 (1.76)

3.77 (2.17)

5 (3.18)

1.83 (1.02)

0.0006 (0.01)

0.73 (73.0)

GR50

Control

2.84

1.33

1.78

1.77

0.07

0.09

Resistant cells

4.77 (1.68)

3.78 (2.84)

3.4 (1.91)

1.93 (1.09)

0.003 (0.04)

0.02 (0.22)

Reversible

5.63 (1.98)

4.54 (3.41)

5.32 (2.99)

1.86 (1.05)

0.007 (0.10)

0.51 (5.67)

GI100

Control

9.48

5.51

6.89

5.41

18.96

16.72

Resistant cells

35.1 (3.70)

23.19 (4.21)

11.94 (1.73)

6.59 (1.22)

16.59 (0.88)

14.61 (0.87)

Reversible

25.24 (2.66)

17.38 (3.15)

16.26 (2.36)

6.17 (1.14)

17.42 (0.92)

14.05 (0.84)

GR100

Control

9.5

5.58

7.07

5.46

19.17

17.19

Resistant cells

30 (3.16)

19.37 (3.47)

12.62 (1.79)

5.99 (1.10)

17.4 (0.91)

15.64 (0.91)

Reversible

32.19 (3.39)

17.91 (3.21)

17.34 (2.45)

5.94 (1.09)

17.96 (0.94)

19.51 (1.13)