Association of body composition with odds of breast cancer by molecular subtype: analysis of the Mechanisms for Established and Novel Risk Factors for Breast Cancer in Nigerian Women (MEND) study

Table 3 Associations between body composition and breast cancer

	Model 1^a OR (95% CI)	Model 2^b aOR (95% CI)	Model 3^c aOR (95% CI)	Model 4^d aOR (95% CI)
BMI (kg/m²) quartile
≤ 22.5	Ref.	Ref.	Ref.	Ref.
> 22.5 - ≤25.6	0.79 (0.52, 1.22)	0.76 (0.49, 1.18)	0.73 (0.44, 1.22)	0.60 (0.31, 1.19)
> 25.6 - ≤29.8	0.68 (0.44, 1.04)	0.65 (0.42, 1.01)	0.63 (0.38, 1.04)	0.38 (0.15, 0.95)
> 29.8	0.60 (0.39, 0.92)	0.56 (0.36, 0.86)	0.56 (0.33, 0.92)	0.32 (0.10, 1.09)
P-trend	*.01*	*.01*	*.02*	.06
aOR (95% CI) per unit SD	0.81 (0.70, 0.94)	0.79 (0.68, 0.93)	0.79 (0.67, 0.95)	0.75 (0.15, 3.72)
Height (cm) quartile
≤ 156.0	Ref.	Ref.	Ref.	Ref.
> 156.0 - ≤160.0	1.05 (0.67, 1.64)	1.07 (0.68, 1.68)	1.05 (0.62, 1.76)	0.90 (0.51, 1.57)
> 160.0 - ≤164.0	1.41 (0.94, 2.10)	1.45 (0.97, 2.16)	1.29 (0.81, 2.05)	1.12 (0.66, 1.90)
> 164.0	1.22 (0.81, 1.84)	1.27 (0.84, 1.91)	1.08 (0.67, 1.73)	0.87 (0.48, 1.60)
P-trend	.17	.13	.55	.85
aOR (95% CI) per unit SD	1.15 (0.99, 1.34)	1.16 (1.00, 1.36)	1.07 (0.90, 1.28)	1.05 (0.56, 1.96)
Weight (kg) quartile
≤ 56.7	Ref.	Ref.	Ref.	Ref.
> 56.7 - ≤65.0	0.85 (0.56, 1.31)	0.84 (0.54, 1.28)	0.75 (0.46, 1.24)	1.09 (0.55, 2.15)
> 65.0 - ≤77.0	0.89 (0.58, 1.37)	0.87 (0.56, 1.34)	0.93 (0.56, 1.57)	2.04 (0.78, 5.29)
> 77.0	0.74 (0.48, 1.14)	0.71 (0.46, 1.10)	0.63 (0.38, 1.04)	1.70 (0.48, 5.98)
P-trend	.22	.16	.14	.31
aOR (95% CI) per unit SD	0.86 (0.74, 1.00)	0.85 (0.73, 0.99)	0.83 (0.69, 0.98)	1.06 (0.20, 5.75)

P-trend based on continuous predictors; aOR per unit SD modeled as a one-unit increase in standard deviation of the variable from its mean-centered value
Bolded values indicate significance at p < .05
Abbreviations: OR odds ratio, CI confidence interval, aOR adjusted odds ratio, SD standard deviation
Logistic regression models predicted odds of breast cancer. ^aModel 1, unadjusted; ^bModel 2, adjusted for age; ^cModel 3, additionally adjusted for clinical and reproductive characteristics: age at menarche, number of pregnancies, number of births, menopausal status, and prior hypertension diagnosis; ^dModel 4, additionally adjusted for all body composition measures: BMI, height, and weight

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