Table 2 Univariate logistic regression analysis for the association between clinicopathological variables and overall toxicity grade ≥ 3
Characteristic | Control (n = 61) n (%) | Case (n = 32) n (%) | OR 95% CI | p-value |
|---|---|---|---|---|
Age median (years) | ||||
  < 59 | 32 (52.5) | 12 (37.5) | Ref. | 0.16 |
  ≥ 59 | 28 (45.9) | 20 (62.5) | 1.83 (0.77–4.49) |  |
Sex | ||||
 Male | 41 (67.2) | 19 (59.4) | Ref. | 0.45 |
 Female | 20 (32.8) | 13 (40.6) | 1.40 (0.57–3.40) |  |
Stage | ||||
 I-II | 20 (32.8) | 7 (21.9) | Ref. | 0.26 |
 III-IV | 41 (67.2) | 25 (78.1) | 1.74 (0.67–4.97) |  |
ECOG | ||||
 0 | 28 (45.9) | 14 (43.8) | Ref. | 0.44 |
 1 | 26 (42.6) | 11 (34.4) | 0.84 (0.32–2.19) |  |
 2 | 1 (1.6) | 2 (6.3) | 4.0 (0.35–90.53) |  |
 NA | 6 (9.8) | 5 (15.6) |  |  |
Lauren histotype | ||||
 Diffuse | 20 (32.8) | 10 (31.3) | Ref. | 0.98 |
 Intestinal | 17 (27.9) | 9 (28.1) | 1.05 (0.34–3.22) |  |
 Mixed | 7 (11.5) | 4 (12.5) | 1.14 (0.25–4.77) |  |
 NA | 17 (27.9) | 9 (28.1) |  |  |
Signet-ring cells | ||||
 No | 35 (57.4) | 19 (59.4) | Ref. | 0.85 |
 Yes | 26 (42.6) | 13 (40.6) | 0.92 (0.38–2.18) |  |
Comorbidities | ||||
 Chronic heart disease | 5 (8.2) | 2 (6.3) | 0.74 (0.10–3.69) | 0.73 |
 Chronic liver disease | 1 (1.1) | 1 (3.3) | 1.93 (0.07–50.06) | 0.64 |
 Thromboembolic event | 1 (1.1) | 1 (3.3) | 1.93 (0.07–50.06) | 0.64 |
 Diabetes | 9 (14.8) | 2 (6.3) | 1.10 (0.26–3.97) | 0.88 |