Table 2 Univariate and multivariate Cox regression analyses of clinicopathologic factors with overall survival in high- and low-grade SEER training set

Age

< 0.001

< 0.001

< 0.001

  < =66

Ref

Ref

Ref

<=71

Ref

Ref

Ref

 67–80

1.609

1.411–1.833

< 0.001

1.585

1.387–1.811

< 0.001

1.631

1.427–1.864

< 0.001

> 71

2.734

2.008–3.724

< 0.001

2.842

2.064–3.913

< 0.001

2.938

2.129–4.053

< 0.001

  > 80

2.567

2.223–2.964

< 0.001

2.389

2.051–2.782

< 0.001

2.444

2.099–2.846

< 0.001

–

–

–

–

–

–

–

–

–

 male

Ref

Ref

–

–

 female

1.045

0.940–1.160

0.415

–

–

–

–

–

–

1.084

0.800–1.468

0.602

–

–

–

–

–

–

Race

0.641

–

–

0.946

–

–

 white

Ref

Ref

 black

1.123

0.880–1.434

0.351

–

–

–

–

–

–

1.071

0.502–2.286

0.86

–

–

–

–

–

–

 other

1.018

0.856–1.211

0.837

–

–

–

–

–

–

0.915

0.483–1.735

0.786

–

–

–

–

–

–

 Renal pelvis

Ref

Ref

–

–

 Ureter

0.975

0.871–1.092

0.668

–

–

–

–

–

–

1.139

0.831–1.561

0.419

–

–

–

–

–

–

 left

Ref

Ref

–

–

 right

1.035

0.932–1.149

0.521

–

–

–

–

–

–

0.954

0.706–1.290

0.761

–

–

–

–

–

–

 lll

Ref

I

Ref

–

–

 IV

1.006

0.901–1.122

0.916

–

–

–

–

–

–

II

1.313

0.901–1.912

0.156

–

–

–

–

–

–

  < 65 mm

Ref

Ref

Ref

<=20 mm

Ref

–

–

  > =65 mm

2.085

1.847–2.354

< 0.001

1.311

1.141–1.506

< 0.001

1.447

1.270–1.648

< 0.001

> 20 mm

1.104

0.740–1.647

0.627

–

–

–

–

–

–

Histology

< 0.001

0.001

< 0.001

 Transitional carcinoma

Ref

Ref

Ref

Ref

–

–

 Papillary transitional cell carcinoma

0.541

0.486–0.604

< 0.001

0.802

0.714–0.900

< 0.001

0.779

0.695–0.874

< 0.001

0.791

0.566–1.105

0.17

–

–

–

–

–

–

 0ther

1.246

0.808–1.921

0.32

1.072

0.694–1.658

0.753

1.194

0.774–1.843

0.422

–

–

–

–

–

–

–

–

–

–

AJCC stage

< 0.001

–

< 0.001

< 0.001

–

< 0.001

 I

Ref

Ref

Ref

Ref

Ref

 II

1.428

1.156–1.764

0.001

–

–

–

1.296

1.048–1.604

0.017

1.4

0.910–2.153

0.126

–

–

–

1.417

0.920–2.182

0.114

 lll

2.139

1.797–2.547

< 0.001

–

–

–

1.994

1.667–2.385

< 0.001

2.035

1.388–2.983

< 0.001

–

–

–

2.153

1.465–3.162

< 0.001

 IV

5.245

4.409–6.240

< 0.001

–

–

–

4.873

3.988–5.956

< 0.001

5.699

3.657–8.881

< 0.001

–

–

–

4.217

2.499–7.116

< 0.001

T

< 0.001

< 0.001

–

< 0.001

< 0.001

–

 T1

Ref

Ref

Ref

Ref

Ref

 T2

1.452

1.190–1.771

< 0.001

1.305

1.068–1.594

0.009

–

–

–

1.482

0.980–2.240

0.062

1.476

0.973–2.241

0.067

–

–

–

 T3

2.384

2.030–2.801

< 0.001

2.031

1.716–2.404

< 0.001

–

–

–

2.181

1.512–3.147

< 0.001

2.223

1.531–3.227

< 0.001

–

–

–

 T4

5.838

4.851–7.026

< 0.001

3.18

2.567–3.939

< 0.001

–

–

–

3.932

2.291–6.749

< 0.001

2.6

1.383–4.888

0.003

–

–

–

N

< 0.001

< 0.001

–

< 0.001

< 0.001

–

 N0

Ref

Ref

Ref

Ref

 N1

2.634

2.268–3.059

< 0.001

1.906

1.584–2.294

< 0.001

–

–

–

12.262

6.318–23.797

< 0.001

5.275

2.238–12.434

< 0.001

–

–

–

 N2

2.913

2.464–3.444

< 0.001

2.284

1.854–2.812

< 0.001

–

–

–

23.111

7.079–75.447

< 0.001

7.685

1.788–33.028

0.006

–

–

–

 M0

Ref

Ref

Ref

Ref

Ref

 M1

5.531

4.689–6.525

< 0.001

2.889

2.406–3.470

< 0.001

–

–

–

11.86

5.750–24.461

< 0.001

3.633

1.414–9.333

0.007

–

–

–

 yes

Ref

Ref

Ref

Ref

 no

0.743

0.667–0.827

< 0.001

1.223

1.067–1.401

0.004

1.179

1.045–1.331

0.008

0.774

0.531–1.127

0.181

–

–

–

–

–

–

 yes

Ref

Ref

Ref

Ref

Ref

Ref

 no

0.475

0.398–0.566

< 0.001

0.699

0.583–0.838

< 0.001

0.732

0.611–0.878

0.001

0.268

0.119–0.608

0.002

0.814

0.282–2.347

0.703

0.634

0.249–1.613

0.339

 yes

Ref

Ref

Ref

Ref

Ref

Ref

 no

0.845

0.751–0.950

0.005

1.324

1.157–1.516

< 0.001

1.243

1.088–1.420

0.001

0.468

0.301–0.729

0.001

0.852

0.467–1.555

0.603

0.665

0.388–1.139

0.137