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Table 2 Association between circulating miR-1290 expression and clinicopathologic characteristics in 46 pancreatic cancer patients

From: Circulating MiR-1290 as a potential diagnostic and disease monitoring biomarker of human gastrointestinal tumors

Variable

Total (n = 46)

miR-1290 expression

p value

Low (n = 13)

High (n = 33)

Age (year)

65.48 ± 1.77

69.15 ± 3.53

64.03 ± 2.01

0.195

Sex

   

0.975

 Male

32

9

23

 

 Female

14

4

10

 

BMI (kg/m2)

22.01 (19.69–25.40)

23.26 (20.00–26.88)

21.97 (19.16–25.13)

0.518

Smoke

   

0.057

 Yes

17

2

15

 

 No

29

11

18

 

Alcohol

   

0.164

 Yes

14

2

12

 

 No

32

11

21

 

Hypertension

   

0.818

 Yes

20

6

14

 

 No

26

7

19

 

Diabetes

   

0.813

 Yes

13

4

9

 

 No

33

9

24

 

Location

   

0.894

 Head

29

8

21

 

 Body and tail

17

5

12

 

Tumor size (cm)

3.55 (2.32–4.53)

2.30 (1.80–2.80)

4.00 (2.87–4.60)

0.002**

Lymphatic invasion

   

0.003**

 Positive

35

6

29

 

 Negative

11

7

4

 

Venous invasion

   

0.030*

 Positive

32

6

26

 

 Negative

14

7

7

 

Distant metastasis

   

0.022*

 Positive

23

3

20

 

 Negative

23

10

13

 

Differentiation

   

0.036*

 Well

7

3

4

 

 Moderate

22

9

13

 

Poor

17

1

16

 

TNM stage (AJCC)

   

0.022*

 I and II

23

10

13

 

 III and IV

23

3

20

 

CRP (mg/l)

   

0.624

 < 10

33

10

23

 

 ≥ 10

13

3

10

 

CEA (ng/ml)

   

0.295

 < 5

30

10

20

 

 ≥ 5

16

3

13

 

CA199 (U/ml)

    

 < 37

6

2

4

0.767

 ≥ 37

40

11

29

 

CA125 (U/ml)

   

0.146

 < 35

24

9

15

 

 ≥ 35

22

4

18

 

CA242 (U/ml)

   

0.720

 < 20

16

4

12

 

 ≥ 20

30

9

21

 

CA211 (ng/ml)

   

0.299

 < 5

34

11

23

 

 ≥ 5

12

2

10

 
  1. * p < 0.05, ** p < 0.01