Fig. 5

Circulating miR-1290 is a promising biomarker for disease surveillance. a The tumor growth curve of different groups. Compared to the saline group, tumor growth in 5-FU-treated group was significantly inhibited. b Images of all tumors from nude mouse. Tumors in 5-FU group were significantly smaller than those in saline group. c Comparison of tumor weights between saline group and 5-FU group. Tumors in the saline group were heavier than those in the 5-FU group. d H&E staining of tumors of saline and 5-FU group. The 5-FU group exhibited a large degree of cell apoptosis and necrosis. e The fluctuation of circulating miR-1290 during disease progression and drug treatment in the xenograft mouse model. f Changes of serum miR-1290 levels in CRC patients after surgery were determined by RT-qPCR (n = 10). * p < 0.05, ** p < 0.01, *** p < 0.001