Fig. 1

miR-1290 was upregulated in the tumor tissue and serum of patients with CRC. a Expression of miR-1290 in tumor tissues and paired normal tissues (n = 10). miR-1290 was significantly overexpressed in tumor tissues (p < 0.05). b Venn diagram of the commonly and differentially expressed miRNAs in different groups. 223 (24.9%) miRNAs were only detected in the control group, 139 (15.5%) miRNAs were only detected in the CRC group, and 534 (59.6%) miRNAs were detected in both groups. c Volcano plot of differentially expressed miRNAs. Two hundred sixty-one miRNAs were up-regulated and 395 miRNAs were down-regulated in serum samples from patients with CRC. (p < 0.01, |log2FC| > 1). c Heatmaps of cluster analysis for differentially expressed miRNAs with high expression levels (p < 0.01, |log2FC| > 1). Blue color represents a lower expression level and red color represent a higher expression level. * p < 0.05