Table 4 Results of univariate and multivariable analyses of prognostic factors for overall survival (OS) in 148 patients with oral tongue squamous cell carcinoma receiving surgical resection
Parameters | Number of patients | Univariate analysis | Multivariable analysis | |||
|---|---|---|---|---|---|---|
OS (months) | P value | HR (95% CI) | P value | |||
Age | ||||||
<53y/o | 70 (47%) | 57.7 | 0.43 | |||
≧53y/o | 78 (53%) | 51.1 | ||||
Sex | ||||||
male | 135 (91%) | 51.1 | 0.07 | |||
female | 13 (9%) | NR | ||||
Pathological T status | ||||||
T1 + T2 | 90 (61%) | 82.2 | < 0.001* | |||
T3 + T4 | 58 (39%) | 13.2 | 1.73 (1.11–2.69) | 0.015* | ||
Pathological N status | ||||||
N0 | 79 (53%) | NR | < 0.001* | |||
N1 + 2 + 3 | 69 (47%) | 14.8 | ||||
Pathological 8th AJCC Stage | ||||||
I + II | 60 (41%) | NR | < 0.001* | |||
III + IV | 88 (59%) | 22.5 | ||||
Histologic grade | ||||||
1 | 84 (57%) | 64.5 | 0.18 | |||
2 + 3 | 64 (43%) | 33.0 | ||||
Vascular invasion | ||||||
Absent | 124 (84%) | 68.4 | 0.004* | |||
Present | 24 (16%) | 11.4 | ||||
Perineural invasion | ||||||
Absent | 81 (55%) | 82.2 | 0.022* | |||
Present | 67 (45%) | 30.7 | ||||
Extracapsular extension | ||||||
Absent | 111 (75%) | 76.5 | < 0.001* | |||
Present | 37 (25%) | 11.7 | 2.01 (1.26–3.21) | 0.003* | ||
Surgical margin | ||||||
Negative | 137 (93%) | 57.6 | 0.031* | |||
Positive | 11 (7%) | 13.2 | ||||
Smoking history | ||||||
Absent | 26 (18%) | NR | 0.031* | |||
Present | 122 (82%) | 40.3 | ||||
Alcohol history | ||||||
Absent | 30 (20%) | 68.4 | 0.34 | |||
Present | 118 (80%) | 41.2 | ||||
Betel-nut chewing history | ||||||
Absent | 36 (24%) | NR | 0.16 | |||
Present | 112 (76%) | 45.5 | ||||
UTX expression | ||||||
Overexpression | 64 (43%) | 23.0 | 0.006* | 1.61 (1.05–2.48) | 0.029* | |
Low expression | 84 (57%) | 69.8 | ||||