Table 3 Hazard ratios (95% confident intervals) of esophageal cancer according to quintiles of energy-adjusted dietary intakes of vitamin B12, vitamin B6, folate, and methionine- stratified analysis by alcohol consumption

Vitamin B12

0.18

  Number at risk

9,333

9,956

9,899

9,591

9,224

  Person-years

160,871

168,690

165,816

159,579

153,650

  Case, n

7

11

19

26

23

  Model 2 ^b

1.00 (reference)

1.45 (0.56–3.75)

2.31 (0.96–5.53)

3.27 (1.39–7.66)

2.82 (1.18–6.74)

0.009

  Number at risk

2,554

3,142

3,425

3,697

3,380

  Person-years

44,250

53,644

57,610

61,874

56,835

  Case, n

8

7

12

15

16

  Model 2 ^b

1.00 (reference)

0.70 (0.25–1.94)

1.08 (0.44–2.65)

1.21 (0.50–2.91)

1.28 (0.53–3.09)

0.34

  Number at risk

5,161

3,878

3,665

3,721

4,372

  Person-years

85,509

63,418

60,921

61,546

71,490

  Case, n

65

52

48

45

64

  Model 2 ^b

1.00 (reference)

1.13 (0.78–1.64)

1.09 (0.74–1.61)

0.99 (0.66–1.47)

1.13 (0.78–1.63)

0.66

Vitamin B6

0.89

  Number at risk

9,094

9,602

9,631

9,447

9,150

  Person-years

173,187

181,266

169,377

151,569

133,206

  Case, n

10

16

20

21

19

  Model 2 ^b

1.00 (reference)

1.37 (0.62–3.03)

1.58 (0.73–3.39)

1.69 (0.78–3.64)

1.53 (0.69–3.37)

0.31

  Number at risk

2,627

3,108

3,494

3,622

3,347

  Person-years

45,054

53,227

59,136

61,086

55,710

  Case, n

4

12

15

18

9

  Model 2 ^b

1.00 (reference)

2.23 (0.72–6.94)

2.17 (0.72–6.60)

2.26 (0.75–6.80)

1.11 (0.33–3.68)

0.60

  Number at risk

4,478

3,205

3,385

4,236

5,493

  Person-years

73,024

53,030

56,065

70,334

90,430

  Case, n

61

47

46

43

77

  Model 2 ^b

1.00 (reference)

1.10 (0.75–1.63)

1.00 (0.67–1.48)

0.79 (0.52–1.18)

1.03 (0.72–1.47)

0.83

Folate

0.41

  Number at risk

7,560

9,277

9,946

10,401

10,819

  Person-years

129,722

156,106

166,190

175,262

181464

  Case, n

13

12

19

27

15

  Model 2 ^b

1.00 (reference)

0.74 (0.33–1.69)

1.19 (0.57–2.50)

1.43 (0.71–2.92)

0.76 (0.35–1.69)

0.80

  Number at risk

2,662

3,339

3,454

3,397

3,346

  Person-years

45,040

56,139

58,275

57,803

56,956

  Case, n

10

9

13

20

6

  Model 2 ^b

1.00 (reference)

0.65 (0.26–1.61)

0.93 (0.40–2.14)

1.40 (0.64–3.05)

0.40 (0.14–1.12)

0.30

  Number at risk

6,891

4,389

3,546

3,183

2,788

  Person-years

112,892

72,205

58,818

52,931

46,036

  Case, n

84

58

44

42

46

  Model 2 ^b

1.00 (reference)

1.12 (0.79–1.57)

1.06 (0.73–1.54)

1.05 (0.72–1.55)

1.30 (0.89–1.89)

0.25

Methionine

0.02

  Number at risk

8,214

10,251

10,241

9,929

9,368

  Person-years

141,928

174,731

172,663

164,817

154,605

  Case, n

5

13

11

25

32

  Model 2 ^b

1.00 (reference)

2.02 (0.72–5.68)

1.52 (0.52–4.38)

2.92 (1.10–7.71)

3.45 (1.32–9.06)

0.003

  Number at risk

2,031

2,743

3,445

4,001

3,978

  Person-years

34,893

47,437

57,881

67,544

66,457

  Case, n

4

10

14

16

14

  Model 2 ^b

1.00 (reference)

1.68 (0.53–5.37)

1.54 (0.50–4.74)

1.37 (0.45–4.14)

1.06 (0.34–3.27)

0.52

  Number at risk

6,852

3,956

3,309

3,067

3,613

  Person-years

112,220

65,083

54,758

51,056

59,764

  Case, n

98

65

28

32

51

  Model 2 ^b

1.00 (reference)

1.23 (0.89–1.70)

0.64 (0.42–0.99)

0.80 (0.53–1.22)

1.03 (0.72–1.48)

0.68