Table 1 Baseline characteristics of the participants according to quintiles of energy-adjusted dietary intakes of vitamin B12, vitamin B6, folate, and methionine

 No. of participants

17,410

17,411

17,411

17,411

17,410

 Male, n (%)

8,003 (46.0)

7,555 (43.4)

7,978 (45.8)

8,290 (47.6)

8,890 (51.1)

<.0001

 Age, years ^c

56.2 ± 7.9

56.7 ± 8.0

56.8 ± 8.0

57.2 ± 7.7

57.7 ± 7.5

<.0001

 BMI, kg/m^{2 c}

23.8 ± 3.5

23.7 ± 3.5

23.5 ± 3.2

23.5 ± 3.3

23.5 ± 3.4

<.0001

 Current smokers, n (%)

3,877 (22.3)

3,672 (21.1)

3,783 (21.7)

3,927 (22.6)

4,396 (25.3)

<.0001

 Family history of cancer, yes (n [%])

2,249 (12.9)

2,454 (14.1)

2,627 (15.1)

2,829 (16.3)

2,828 (16.2)

<.0001

 METs unit ^c

34.2 ± 6.3

33.5 ± 6.0

33.2 ± 5.9

33.3 ± 6.0

33.6 ± 6.1

<.0001

 Alcohol consumption, ethanol g/week ^c

163.9 ± 299.4

94.8 ± 180.3

84.6 ± 163.8

85.8 ± 162.5

102.7 ± 180.7

<.0001

 Alcohol, n (%)

0.004

  Non-drinkers

9,333 (53.6)

9,956 (57.2)

9,899 (56.9)

9,591 (55.1)

9,224 (53.0)

  ≤150 g/week

2,554 (14.7)

3,139 (18.0)

3,425 (19.7)

3,695 (21.2)

3,380 (19.4)

  150<alcohol≤300 g/week

1,282 (7.4)

1,497 (8.6)

1,646 (9.5)

1,672 (9.6)

1,827 (10.5)

  300<alcohol<450 g/week

1,260 (7.2)

1,158 (6.7)

1,107 (6.4)

1,134 (6.5)

1,302 (7.5)

  ≥450 g/week

2,619 (15.0)

1,226 (7.0)

912 (5.2)

917 (5.3)

1,243 (7.1)

  Energy, kcal/day ^c

2,398.1 ± 710.5

1,859.0 ± 572.3

1,774.0 ± 602.0

1,854.9 ± 627.3

2,218.3 ± 746.4

<.0001

  Vitamin B6, mg/day ^c

1.3 ± 0.4

1.4 ± 0.2

1.5 ± 0.2

1.6 ± 0.2

1.9 ± 0.4

<.0001

  Vitamin B12, μg/day ^c

3.7 ± 2.6

7.4 ± 0.6

9.3 ± 0.6

11.6 ± 0.8

18.3 ± 6.7

<.0001

  Folate, μg/day ^c

361.8 ± 200.0

392.5 ± 135.3

406.5 ± 127.7

425.6 ± 132.1

453.7 ± 166.4

<.0001

  Methionine, mg/day ^c

1,293.0 ± 363.3

1,525.3 ± 215.1

1,638.0 ± 211.3

1,763.6 ± 230.0

2,079.1 ± 469.0

<.0001

 No. of participants

17,410

17,411

17,411

17,411

17,410

 Male, n (%)

6,848 (39.3)

6,429 (36.9)

7,768 (44.6)

9,091 (52.2)

10,580 (60.8)

<.0001

 Age, years ^c

55.0 ± 7.6

56.3 ± 7.9

57.2 ± 7.9

57.7 ± 7.7

58.5 ± 7.6

<.0001

 BMI, kg/m^2c

23.7 ± 3.4

23.5 ± 3.3

23.5 ± 3.3

23.6 ± 3.5

23.7 ± 3.4

0.05

 Current smokers, n (%)

4,237 (24.3)

3,511 (20.2)

3,654 (21.0)

3,986 (22.9)

4,268 (24.5)

<.0001

 Family history of cancer, yes (n [%])

2,191 (12.6)

2,423 (13.9)

2,673 (15.4)

2,744 (15.8)

2,956 (17.0)

<.0001

 METs unit ^c

33.8 ± 6.2

33.2 ± 5.9

33.4 ± 6.0

33.5 ± 6.1

33.8 ± 6.2

<.0001

 Alcohol consumption, ethanol g/week ^c

151.1 ± 296.8

80.5 ± 172.6

80.8 ± 163.6

95.1 ± 167.8

124.1 ± 188.7

<.0001

 Alcohol, n (%)

<.0001

  Non-drinkers

9,988 (57.4)

1,0644 (61.1)

10,082 (57.9)

9,151 (52.6)

8,135 (46.7)

  ≤150 g/week

2,627 (15.1)

3,104 (17.8)

3,494 (20.1)

3,621 (20.8)

3,347 (19.2)

  150<alcohol≤300 g/week

1,060 (6.1)

1,269 (7.3)

1,465 (8.4)

1,916 (11.0)

2,214 (12.7)

  300<alcohol<450 g/week

824 (4.7)

912 (5.2)

1,043 (6.0)

1,338 (7.7)

1,845 (10.6)

  ≥450 g/week

2,590 (14.9)

1,031 (5.9)

875 (5.0)

984 (5.7)

1,434 (8.2)

  Energy, kcal/day ^c

2,265.4 ± 735.6

1,833.1 ± 615.5

1,817.3 ± 609.6

1,917.5 ± 623.3

2,270.8 ± 742.7

<.0001

  Vitamin B6, mg/day ^c

1.1 ± 0.2

1.4 ± 0.04

1.5 ± 0.04

1.7 ± 0.1

2.1 ± 0.3

<.0001

  Vitamin B12, μg/day ^c

5.7 ± 4.0

8.5 ± 3.2

9.7 ± 3.5

11.2 ± 4.2

15.0 ± 8.2

<.0001

  Folate, μg/day ^c

280.8 ± 109.9

364.3 ± 94.4

405.6 ± 102.8

449.7 ± 121.3

539.6 ± 202.7

<.0001

  Methionine, mg/day ^c

1,377.7 ± 371.2

1,561.9 ± 242.1

1,644.6 ± 252.9

1,736.3 ± 286.3

1,978.2 ± 544.5

<.0001

 No. of participants

17,410

17,411

17,411

17,411

17,410

<.0001

 Male, n (%)

10,072 (57.9)

8,732 (50.2)

7,646 (43.9)

7,310 (42.0)

6,956 (40.0)

<.0001

 Age, years ^c

54.9 ± 7.5

56.3 ± 7.9

57.0 ± 7.9

57.8 ± 7.8

58.7 ± 7.7

<.0001

 BMI, kg/m^{2 c}

23.7 ± 3.3

23.6 ± 3.4

23.5 ± 3.3

23.6 ± 3.4

23.6 ± 3.5

0.03

 Current smokers, n (%)

5,664 (32.5)

4,148 (23.8)

3,557 (20.4)

3,254 (18.7)

3,033 (17.4)

<.0001

 Family history of cancer, yes (n [%])

2,222 (12.8)

2,343 (13.5)

2,650 (15.2)

2,814 (16.2)

2,958 (17.0)

<.0001

 METs unit ^c

33.9 ± 6.4

33.3 ± 6.1

33.3 ± 6.0

33.6 ± 6.0

33.7 ± 6.0

0.004

 Alcohol consumption, ethanol g/week ^c

209.3 ± 311.1

103.7 ± 182.4

82.0 ± 159.2

72.6 ± 150.4

63.4 ± 140.6

<.0001

 Alcohol intake, n (%)

<.0001

  Non-drinkers

7,560 (43.4)

9,272 (53.3)

9,943 (57.1)

10,401 (59.7)

10,819 (62.1)

  ≤150 g/week

2,661 (15.3)

3,338 (19.2)

3,452 (19.8)

3,397 (19.8)

3,345 (19.2)

  150<alcohol≤300 g/week

1,695 (9.7)

1,797 (10.3)

1,600 (9.2)

1,490 (8.6)

1,342 (7.7)

  300<alcohol<450 g/week

1,701 (9.8)

1,346 (7.7)

1,087 (6.2)

956 (5.5)

871 (5.0)

  ≥450 g/week

3,496 (20.1)

1,247 (7.2)

861 (5.0)

737 (4.2)

576 (3.3)

  Energy, kcal/day ^c

2,335.4 ± 727.8

1,880.2 ± 634.5

1,837.6 ± 622.5

1,910.2 ± 645.3

2,140.9 ± 725.3

<.0001

  Vitamin B6, mg/day ^c

1.3 ± 0.4

1.5 ± 0.3

1.6 ± 0.3

1.6 ± 0.3

1.8 ± 0.4

<.0001

  Vitamin B12, μg/day ^c

8.0 ± 6.7

9.7 ± 4.7

10.4 ± 4.9

10.8 ± 5.0

11.4 ± 6.9

<.0001

  Folate, μg/day ^c

224.5 ± 68.2

326.7 ± 18.4

388.1 ± 18.0

461.6 ± 26.1

639.2 ± 146.7

<.0001

  Methionine, mg/day ^c

1,547.7 ± 525.4

1,655.1 ± 346.1

1,691.4 ± 342.1

1,706.8 ± 348.6

1,698.1 ± 428.7

<.0001

 No. of participants

17,410

17,411

17,411

17,411

17,410

 Male, n (%)

7,924 (45.5)

6,273 (36.0)

7,211 (41.4)

8,748 (50.2)

10,560 (60.7)

<.0001

 Age, years ^c

55.7 ± 7.8

56.7 ± 7.9

57.1 ± 8.0

57.3 ± 7.8

57.8 ± 7.6

<.0001

 BMI, kg/m^{2 c}

23.6 ± 3.4

23.6 ± 3.5

23.6 ± 3.4

23.6 ± 3.3

23.6 ± 3.3

0.06

 Current-smokers, n (%)

4,620 (26.5)

3,364 (19.3)

3,439 (19.8)

3,811 (21.9)

4,422 (25.4)

<.0001

 Family history of cancer, yes (n [%])

2,460 (14.1)

2,519 (14.5)

2,667 (15.3)

2,649 (15.2)

2,692 (15.5)

0.006

 METs unit ^c

34.2± 6.3

33.5 ± 6.0

33.3 ± 5.9

33.2 ± 6.0

33.4± 6.1

<.0001

 Alcohol intake, ethanol g/week ^c

221.4 ± 329.4

90.4± 167.2

71.8 ± 139.4

67.0 ± 131.4

80.8 ± 148.2

<.0001

 Alcohol intake, n (%)

<.0001

  Non-drinkers

8,214 (47.2)

10,251 (58.9)

10,241 (58.8)

9,929 (57.0)

9,368 (53.8)

  ≤150 g/week

2,031 (11.7)

2,743 (15.8)

3,445 (19.8)

4,001 (23.0)

3,978 (22.9)

  150<alcohol≤300 g/week

1,249 (7.2)

1,532 (8.8)

1,635 (9.4)

1,665 (9.6)

1,843 (10.6)

  300<alcohol<450 g/week

1,692 (9.7)

1,326 (7.6)

1,023 (5.9)

881 (5.1)

1,039 (6.0)

  ≥450 g/week

3,911 (22.5)

1,100 (6.3)

654 (3.8)

521 (3.0)

731 (4.2)

  Energy, kcal/day ^c

2,323.2 ± 701.9

1,859.0 ± 594.3

1,799.7 ± 602.0

1,866.1 ± 622.7

2,256.3 ± 774.2

<.0001

  Vitamin B6, mg/day ^c

1.3 ± 0.4

1.5 ± 0.2

1.5 ± 0.2

1.6 ± 0.2

1.9 ± 0.4

<.0001

  Vitamin B12, μg/day ^c

5.0 ± 3.7

8.0 ± 2.7

9.6 ± 2.8

11.4 ± 3.5

16.2 ± 7.9

<.0001

  Folate, μg /day ^c

378.4 ± 202.1

401.1 ± 141.2

410.2 ± 130.6

420.0 ± 134.4

430.4 ± 164.4

<.0001

  Methionine, mg/day ^c

1,169.7 ± 247.7

1,485.1 ± 47.3

1,633.3 ± 41.6

1,797.1 ± 56.3

2,213.9 ± 411.9

<.0001