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Table 3 Association of selected alleles in BRCA1, PALB2, CHEK2 and NBN with risk of male breast cancer

From: Genetic predisposition to male breast cancer in Poland

Gene Mutation All patients Controla  
   Positive Total % Positive Total % OR 95%CI p-value
BRCA1 c.5263_5264insC 1 165 0.6% 13 4000 0.32% 1.87 0.24–14.38 0.54
c.181 T > G 0 165 0.0% 3 4000 0.08%  
c.4035delA 0 165 0.0% 1 4000 0.03%  
Any BRCA1 1 165 0.6% 17 4000 0.42% 1.43 0.19–10.80 0.73
PALB2 509_510delGA 4 165 2.4% 7 4702 0.1% 16.70 4.83–57.50 < 0.001
172_175deITTGT 0 165 0.0% 3 4702 0.05%  
Any PALB2 4 165 2.4% 10 4702 0.15% 11.66 3.62–37.57 < 0.001
CHEK2 1100delC 3 165 1.8% 12 5496 0.2% 8.46 2.37–30.29 0.001
c.444 + 1G > A 1 165 0.6% 22 5496 0.4% 1.52 0.20–11.32 0.68
del5395 (ex10-11del) 1 165 0.6% 24 5496 0.4% 1.39 0.19–10.34 0.75
CHEK2 truncating 5 165 3.0% 58 5496 1.1% 2.93 1.16–7.40 0.02
c.470C > T 9 165 5.5% 264 5496 4.8% 1.28 0.59–2.17 0.84
Any CHEK2 14 165 8.5% 321 5496 5.8% 1.45 0.87–2.42 0.21
NBN c.657_661delACAAA 1 165 0.6% 22 4000 0.55% 1.10 0.15–8.23 0.92