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Table 2 The frequencies of mutation detected in study in a series of 165 male breast cancer patients by family history of breast and ovarian cancer

From: Genetic predisposition to male breast cancer in Poland

Mutations All patients
(n = 165)
Family History
Positive
(n = 52)
Family History
Negative
(n = 113)
Chi-square test
  N % N % N % p
Any BRCA1 1 0.6 1 1.9 0 0.0 0.14
c.5263_5264insC 1 0.6 1 1.9 0 0.0  
c.181 T > G 0 0.0 0 0.0 0 0.0  
c.4035delA 0 0.0 0 0.0 0 0.0  
c.3700_3704delGTAAA 0 0.0 0 0.0 0 0.0  
c.68_69delAG 0 0.0 0 0.0 0 0.0  
c.5251C > T 0 0.0 0 0.0 0 0.0  
c.3756_3759delGTCT 0 0.0 0 0.0 0 0.0  
Any BRCA2 2 1.2 1 1.9 1 0.9 0.57
c.658_659delGT 1 0.6 1 1.9 0 0.0  
c.5946delT 1 0.6 0 0.0 1 0.9  
c.3847_3848delGT 0 0.0 0 0.0 0 0.0  
c.5239_5240insT 0 0.0 0 0.0 0 0.0  
c.7913_7917del5 0 0.0 0 0.0 0 0.0  
Any PALB2 4 2.4 3 5.8 1 0.9 0.57
c.509_510delGA 4 2.4 3 5.8 1 0.9  
c.172_175deITTGT 0 0.0 0 0.0 0 0.0  
Any CHEK2 14 8.5 4 7.7 10 8.8 0.80
CHEK2 truncating 5 3.0 2 3.85 3 2.7 0.68
c.100delC 3 1.8 1 1.9 2 1.8  
c.444 + 1G > A 1 0.6 1 1.9 0 0.0  
del5395(ex10-11del) 1 0.6 0 0.0 1 0.9  
c.470C > T 9 5.5 2 3.85 7 6.2  
NBN c.657_661delACAAA 1 0.6 0 0.0 1 0.9 0.50
RECQL c.1667_1667 + 3delAGTA 0 0.0 0 0.0 0 0.0
  1. BC breast cancer, OV ovarian cancer