Table 2 The frequencies of mutation detected in study in a series of 165 male breast cancer patients by family history of breast and ovarian cancer
From: Genetic predisposition to male breast cancer in Poland
Mutations | All patients (n = 165) | Family History Positive (n = 52) | Family History Negative (n = 113) | Chi-square test | |||
|---|---|---|---|---|---|---|---|
| Â | N | % | N | % | N | % | p |
Any BRCA1 | 1 | 0.6 | 1 | 1.9 | 0 | 0.0 | 0.14 |
c.5263_5264insC | 1 | 0.6 | 1 | 1.9 | 0 | 0.0 | Â |
c.181 T > G | 0 | 0.0 | 0 | 0.0 | 0 | 0.0 |  |
c.4035delA | 0 | 0.0 | 0 | 0.0 | 0 | 0.0 | Â |
c.3700_3704delGTAAA | 0 | 0.0 | 0 | 0.0 | 0 | 0.0 | Â |
c.68_69delAG | 0 | 0.0 | 0 | 0.0 | 0 | 0.0 | Â |
c.5251C > T | 0 | 0.0 | 0 | 0.0 | 0 | 0.0 |  |
c.3756_3759delGTCT | 0 | 0.0 | 0 | 0.0 | 0 | 0.0 | Â |
Any BRCA2 | 2 | 1.2 | 1 | 1.9 | 1 | 0.9 | 0.57 |
c.658_659delGT | 1 | 0.6 | 1 | 1.9 | 0 | 0.0 | Â |
c.5946delT | 1 | 0.6 | 0 | 0.0 | 1 | 0.9 | Â |
c.3847_3848delGT | 0 | 0.0 | 0 | 0.0 | 0 | 0.0 | Â |
c.5239_5240insT | 0 | 0.0 | 0 | 0.0 | 0 | 0.0 | Â |
c.7913_7917del5 | 0 | 0.0 | 0 | 0.0 | 0 | 0.0 | Â |
Any PALB2 | 4 | 2.4 | 3 | 5.8 | 1 | 0.9 | 0.57 |
c.509_510delGA | 4 | 2.4 | 3 | 5.8 | 1 | 0.9 | Â |
c.172_175deITTGT | 0 | 0.0 | 0 | 0.0 | 0 | 0.0 | Â |
Any CHEK2 | 14 | 8.5 | 4 | 7.7 | 10 | 8.8 | 0.80 |
CHEK2 truncating | 5 | 3.0 | 2 | 3.85 | 3 | 2.7 | 0.68 |
c.100delC | 3 | 1.8 | 1 | 1.9 | 2 | 1.8 | Â |
c.444 + 1G > A | 1 | 0.6 | 1 | 1.9 | 0 | 0.0 |  |
del5395(ex10-11del) | 1 | 0.6 | 0 | 0.0 | 1 | 0.9 | Â |
c.470C > T | 9 | 5.5 | 2 | 3.85 | 7 | 6.2 |  |
NBN c.657_661delACAAA | 1 | 0.6 | 0 | 0.0 | 1 | 0.9 | 0.50 |
RECQL c.1667_1667 + 3delAGTA | 0 | 0.0 | 0 | 0.0 | 0 | 0.0 | – |