Adjuvant chemotherapy is an additional option for locally advanced gastric cancer after radical gastrectomy with D2 lymphadenectomy: a retrospective control study

Table 6 Univariate and multivariate analysis of clinicopathologic factors for DFS

Variables	Univariate			Multivariate
Variables	HR	95% CI	P	HR	95% CI	P
Age (years)
< 60 yr	1.000
≥ 60 yr	1.297	0.955–1.760	0.096			0.301
Sex
Male	1.000
Female	1.208	0.873–1.671	0.254
BMI
< 23	1.000
≥ 23	0.970	0.714–1.318	0.847
Surgical approach
Traditional open	1.000
Laparoscopic-assisted	0.802	0.576–1.116	0.191			0.264
Intraoperative blood loss
≤ 100 ml	1.000			1.000
>100 ml	1.777	1.252–2.522	0.001	1.829	1.279–2.615	0.001
Postoperative complications
Negative	1.000
Positive	1.365	0.892–2.090	0.151			0.838
Tumor length/diameter
< 5 cm	1.000
≥ 5 cm	1.929	1.421–2.619	< 0.001			0.053
Histological type
HD/MD/M-LD	1.000
LD/MA/SRC	1.506	1.108–2.047	0.009			0.129
Vascular tumor embolus
Negative	1.000
Positive	1.779	1.285–2.464	0.001			0.901
Depth of Invasion (T)
T1/T2/T3	1.000
T4a/T4b	2.149	1.572–2.939	< 0.001			0.207
Lymph node metastasis (N)
N0/N1	1.000
N2/N3	2.650	1.897–3.701	< 0.001			0.690
TNM			< 0.001			< 0.001
IIA
IIB	2.748	1.380–5.469	0.004	2.634	1.323–5.246	0.006
IIIA	3.216	1.715–6.033	< 0.001	3.347	1.783–6.281	< 0.001
IIIB	6.268	3.340–11.762	< 0.001	6.941	3.687–13.065	< 0.001
IIIC	12.823	6.476–25.392	< 0.001	13.420	6.751–26.677	< 0.001
Serum CEA level
≤ 5 ng/ml	1.000
>5 ng/ml	1.022	0.701–1.490	0.911
Serum CA199 level
≤ 37 U/ml	1.000
>37 U/ml	1.291	1.057–1.578	0.012			0.840
Adjuvant chemotherapy cycles			0.002			< 0.001
Not received (A)	1.000			1.000
7–8 or 10–12 cycles (B)	0.549	0.369–0.817	0.003	0.424	0.283–0.635	< 0.001
4–6 or 6–9 cycles (C)	0.592	0.381–0.918	0.019	0.522	0.335–0.815	0.004
≤ 3 or 5 cycles (D)	1.058	0.664–1.687	0.812	0.836	0.519–1.349	0.464

Note: HD/MD/M-LD High/Median/Median-Low differentiation adenocarcinoma, LD/MA/SRC Low differentiation adenocarcinoma/Mucinous adeno-carcinoma/ Signet-ring cell carcinoma, HR Hazard ratio, CI Confidence interval. P < 0.05, statistically significant

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