Skip to main content

Table 2 Univariate and multivariate analysis for predictive factors associated with postoperative overall survival in glioblastoma patients

From: Prognostic significance of the postoperative prognostic nutritional index in patients with glioblastoma: a retrospective study

  Univariate analysis Multivariate analysis*
Odds ratio 95% CI P value Odds ratio 95% CI P value
Age < 60 years (n) 2.50 1.29–4.84 0.007 2.07 1.02–4.21 0.045
Male gender (n) 0.59 0.33–1.05 0.070    
Preoperative KPS score ≥ 70 (n) 1.07 0.42–2.69 0.891    
KPS score at hospital discharge ≥70 (n) 3.11 0.93–10.43 0.066    
Albumin (g/dL)
 Preoperative 1.93 0.93–4.01 0.078    
 Postoperative 3.43 1.47–7.98 0.004    
High preoperative PNI (PNI ≥ 50. 1) (n) 2.26 1.25–4.10 0.007    
High postoperative PNI (PNI ≥ 50. 2) (n) 2.39 1.34–4.26 0.003 2.17 1.14–4.10 0.018
Extent of surgical resection    0.083    
 Gross total resection Reference      
 Near total resection 0.09 0.01–0.70 0.021    
 Subtotal resection 0.64 0.39–1.40 0.268    
 Partial resection 0.26 0.03–2.03 0.199    
 Biopsy 0.36 0.05–2.92 0.342    
Postoperative new neurologic deficit (n) 0.61 0.27–1.35 0.220    
Gene expression profiles (n)
 MGMT Promoter methylation 2.62 1.40–4.89 0.003 2.61 1.33–5.11 0.005
 IDH mutation 2.08 1.03–4.19 0.041    
Completed Stupp protocol (n) 5.84 2.56–13.32 <  0.001 5.39 2.18–13.27 <  0.001
  1. KPS Karnofsky performance status, PNI prognostic nutritional index, MGMT O6-methylguanine-DNA methyltransferase, IDH isocitrate dehydrogenase, RT radiation therapy. *Multivariate analysis with the forward stepwise conditional method was performed and male gender, preoperative KPS score ≥ 70, KPS score at hospital discharge ≥70, preoperative and postoperative serum albumin level, high preoperative PNI, the extent of surgical resection, postoperative new neurologic deficit, IDH mutation, were adjusted. Nagelkerke R2 statistic in step 4 is 0.208