Prognostic significance of the postoperative prognostic nutritional index in patients with glioblastoma: a retrospective study

Table 2 Univariate and multivariate analysis for predictive factors associated with postoperative overall survival in glioblastoma patients

	Univariate analysis			Multivariate analysis*
	Odds ratio	95% CI	P value	Odds ratio	95% CI	P value
Age < 60 years (n)	2.50	1.29–4.84	0.007	2.07	1.02–4.21	0.045
Male gender (n)	0.59	0.33–1.05	0.070
Preoperative KPS score ≥ 70 (n)	1.07	0.42–2.69	0.891
KPS score at hospital discharge ≥70 (n)	3.11	0.93–10.43	0.066
Albumin (g/dL)
Preoperative	1.93	0.93–4.01	0.078
Postoperative	3.43	1.47–7.98	0.004
High preoperative PNI (PNI ≥ 50. 1) (n)	2.26	1.25–4.10	0.007
High postoperative PNI (PNI ≥ 50. 2) (n)	2.39	1.34–4.26	0.003	2.17	1.14–4.10	0.018
Extent of surgical resection			0.083
Gross total resection	Reference
Near total resection	0.09	0.01–0.70	0.021
Subtotal resection	0.64	0.39–1.40	0.268
Partial resection	0.26	0.03–2.03	0.199
Biopsy	0.36	0.05–2.92	0.342
Postoperative new neurologic deficit (n)	0.61	0.27–1.35	0.220
Gene expression profiles (n)
MGMT Promoter methylation	2.62	1.40–4.89	0.003	2.61	1.33–5.11	0.005
IDH mutation	2.08	1.03–4.19	0.041
Completed Stupp protocol (n)	5.84	2.56–13.32	< 0.001	5.39	2.18–13.27	< 0.001

KPS Karnofsky performance status, PNI prognostic nutritional index, MGMT O6-methylguanine-DNA methyltransferase, IDH isocitrate dehydrogenase, RT radiation therapy. *Multivariate analysis with the forward stepwise conditional method was performed and male gender, preoperative KPS score ≥ 70, KPS score at hospital discharge ≥70, preoperative and postoperative serum albumin level, high preoperative PNI, the extent of surgical resection, postoperative new neurologic deficit, IDH mutation, were adjusted. Nagelkerke R² statistic in step 4 is 0.208

ISSN: 1471-2407