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Table 2 Cox Univariate and Multivariate Analysis

From: Comprehensive analysis of coagulation indices for predicting survival in patients with biliary tract cancer

Variates Cases (n = 300) Univariate analysis Multivariate analysis
HR (95% CI) P HR (95% CI) P
Age (year)
 ≤ 60 142 Reference    
 > 60 158 1.190 (0.898–1.576) 0.225   
Sex
 Female 139 Reference    
 Male 161 0.926 (0.699–1.226) 0.591   
Tumor Differentiation [286]     
 Poor 106 Reference   Reference  
 Modest-well 180 0.656 (0.490–0.878) 0.005 * 0.766 (0.555–1.057) 0.104
Tumor size (cm) [282]     
 ≤ 2 126 Reference   Reference  
 > 2 156 1.379 (1.028–1.851) 0.032 * 1.066 (0.766–1.484) 0.703
TNM stage    < 0.001   0.001
 I 100 Reference   Reference  
 II 84 1.521 (1.043–2.218) 0.029 * 1.709 (1.124–2.598) 0.012 *
 III 82 1.626 (1.117–2.366) 0.011 * 1.727 (1.139–2.620) 0.010 *
 IV 34 3.648 (2.340–5.687) 0.000 * 2.637 (1.608–4.325) < 0.001 *
Curative surgery [297]     
 No 123 Reference   Reference  
 Yes 174 0.367 (0.276–0.488) < 0.001 * 0.438 (0.312–0.616) < 0.001 *
Jaundice
 No 136 Reference    
 Yes 164 1.217 (0.917–1.615) 0.174   
Diabetes
 No 246 Reference    
 Yes 54 1.016 (0.709–1.454) 0.933   
Hypertension
 No 201 Reference    
 Yes 99 1.029 (0.762–1.389) 0.852   
Fatty liver
 No 278 Reference    
 Yes 22 1.168 (0.689–1.980) 0.564   
Liver cirrhosis
 No 288 Reference    
 Yes 12 1.619 (0.879–2.980) 0.122   
FBG (g/L)
 ≤ 3.61 134 Reference   Reference  
 > 3.61 166 1.918 (1.431–2.571) < 0.001 * 1.478 (1.054–2.073) 0.023 *
PT (s)
 ≤ 11.0 67 Reference   Reference  
 > 11.0 233 1.587 (1.103–2.281) 0.013 * 1.251 (0.782–2.002) 0.350
PTA (%)
 ≤ 94.0 177 Reference   Reference  
 > 94.0 123 0.718 (0.538–0.968) 0.025 * 1.535 (0.921–2.558) 0.100
INR
 ≤ 0.98 143 Reference   Reference  
 > 0.98 157 1.585 (1.194–2.105) 0.001 * 1.879 (1.141–3.093) 0.013 *
APTT (s)
 ≤ 26.5 154 Reference   Reference  
 > 26.5 146 1.382 (1.042–1.832) 0.025 * 1.367 (0.212–8.820) 0.743
APTT-R
 ≤ 0.98 153 Reference   Reference  
 > 0.98 147 1.380 (1.041–1.831) 0.025 * 0.742 (0.113–4.856) 0.755
TT (s)
 ≤ 16.9 45 Reference    
 > 16.9 255 0.760 (0.520–1.110) 0.156   
PLT (×109/L)
 ≤ 301 239 Reference    
 > 301 61 1.223 (0.874–1.711) 0.240   
CA19–9 (U/mL) [290]     
 ≤ 37 83 Reference   Reference  
 > 37 207 2.366 (1.654–3.386) < 0.001 * 1.644 (1.089–2.482) 0.018 *
ALT (U/L)
 ≤ 40 121 Reference    
 > 40 179 1.076 (0.808–1.433) 0.615   
AST (U/L)
 ≤ 40 132 Reference    
 > 40 158 1.092 (0.820–1.455) 0.548   
GGT (U/L) [293]     
 ≤ 40 55 Reference   Reference  
 > 40 238 1.844 (1.219–2.791) 0.004 * 1.115 (0.673–1.848) 0.671
ALB (g/L) [299]     
 ≤ 35 58 Reference    
 > 35 241 0.794 (0.567–1.112) 0.179   
  1. Asterisks indicated P-values of statistical significance. Continuous variables were shown as medians and ranges, and categorical variables were reported as numbers and percentages. For variables with missing data, the numbers of available cases were shown in square brackets