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Table 2 Cox Univariate and Multivariate Analysis

From: Comprehensive analysis of coagulation indices for predicting survival in patients with biliary tract cancer

Variates

Cases (n = 300)

Univariate analysis

Multivariate analysis

HR (95% CI)

P

HR (95% CI)

P

Age (year)

 ≤ 60

142

Reference

   

 > 60

158

1.190 (0.898–1.576)

0.225

  

Sex

 Female

139

Reference

   

 Male

161

0.926 (0.699–1.226)

0.591

  

Tumor Differentiation

[286]

    

 Poor

106

Reference

 

Reference

 

 Modest-well

180

0.656 (0.490–0.878)

0.005 *

0.766 (0.555–1.057)

0.104

Tumor size (cm)

[282]

    

 ≤ 2

126

Reference

 

Reference

 

 > 2

156

1.379 (1.028–1.851)

0.032 *

1.066 (0.766–1.484)

0.703

TNM stage

  

< 0.001

 

0.001

 I

100

Reference

 

Reference

 

 II

84

1.521 (1.043–2.218)

0.029 *

1.709 (1.124–2.598)

0.012 *

 III

82

1.626 (1.117–2.366)

0.011 *

1.727 (1.139–2.620)

0.010 *

 IV

34

3.648 (2.340–5.687)

0.000 *

2.637 (1.608–4.325)

< 0.001 *

Curative surgery

[297]

    

 No

123

Reference

 

Reference

 

 Yes

174

0.367 (0.276–0.488)

< 0.001 *

0.438 (0.312–0.616)

< 0.001 *

Jaundice

 No

136

Reference

   

 Yes

164

1.217 (0.917–1.615)

0.174

  

Diabetes

 No

246

Reference

   

 Yes

54

1.016 (0.709–1.454)

0.933

  

Hypertension

 No

201

Reference

   

 Yes

99

1.029 (0.762–1.389)

0.852

  

Fatty liver

 No

278

Reference

   

 Yes

22

1.168 (0.689–1.980)

0.564

  

Liver cirrhosis

 No

288

Reference

   

 Yes

12

1.619 (0.879–2.980)

0.122

  

FBG (g/L)

 ≤ 3.61

134

Reference

 

Reference

 

 > 3.61

166

1.918 (1.431–2.571)

< 0.001 *

1.478 (1.054–2.073)

0.023 *

PT (s)

 ≤ 11.0

67

Reference

 

Reference

 

 > 11.0

233

1.587 (1.103–2.281)

0.013 *

1.251 (0.782–2.002)

0.350

PTA (%)

 ≤ 94.0

177

Reference

 

Reference

 

 > 94.0

123

0.718 (0.538–0.968)

0.025 *

1.535 (0.921–2.558)

0.100

INR

 ≤ 0.98

143

Reference

 

Reference

 

 > 0.98

157

1.585 (1.194–2.105)

0.001 *

1.879 (1.141–3.093)

0.013 *

APTT (s)

 ≤ 26.5

154

Reference

 

Reference

 

 > 26.5

146

1.382 (1.042–1.832)

0.025 *

1.367 (0.212–8.820)

0.743

APTT-R

 ≤ 0.98

153

Reference

 

Reference

 

 > 0.98

147

1.380 (1.041–1.831)

0.025 *

0.742 (0.113–4.856)

0.755

TT (s)

 ≤ 16.9

45

Reference

   

 > 16.9

255

0.760 (0.520–1.110)

0.156

  

PLT (×109/L)

 ≤ 301

239

Reference

   

 > 301

61

1.223 (0.874–1.711)

0.240

  

CA19–9 (U/mL)

[290]

    

 ≤ 37

83

Reference

 

Reference

 

 > 37

207

2.366 (1.654–3.386)

< 0.001 *

1.644 (1.089–2.482)

0.018 *

ALT (U/L)

 ≤ 40

121

Reference

   

 > 40

179

1.076 (0.808–1.433)

0.615

  

AST (U/L)

 ≤ 40

132

Reference

   

 > 40

158

1.092 (0.820–1.455)

0.548

  

GGT (U/L)

[293]

    

 ≤ 40

55

Reference

 

Reference

 

 > 40

238

1.844 (1.219–2.791)

0.004 *

1.115 (0.673–1.848)

0.671

ALB (g/L)

[299]

    

 ≤ 35

58

Reference

   

 > 35

241

0.794 (0.567–1.112)

0.179

  
  1. Asterisks indicated P-values of statistical significance. Continuous variables were shown as medians and ranges, and categorical variables were reported as numbers and percentages. For variables with missing data, the numbers of available cases were shown in square brackets
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BMC Cancer

ISSN: 1471-2407

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