Table 1 The detailed information of the top 40 survival-related AS events
From: Genome-wide profiling of alternative splicing in glioblastoma and their clinical value
AS_id | symbol | splice_type | exons | from_exon | to_exon | novel_splice | pct_with_values | psi_range | std_psi | AveExp | z | HR | HR.95 L | HR.95H | FDR value |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
78,181 | SYNE1 | AT | 152 | null | null | 0 | 1 | 0.5308 | 0.0544 | 0.962424 | −4.13214 | 9.94E-05 | 1.26E-06 | 0.00787 | 3.59E-05 |
76,352 | TMEM63B | AP | 1 | null | null | 0 | 0.7812 | 0.6292 | 0.1019 | 0.133696 | 4.04969 | 77.79737 | 9.457538 | 639.9583 | 5.13E-05 |
60,221 | USP25 | ES | 20 | 18 | 21 | 0 | 0.9937 | 0.225 | 0.0486 | 0.072053 | −3.82103 | 0.000223 | 3.00E-06 | 0.016666 | 0.000133 |
36,699 | CDH11 | ES | 3 | 2 | 4 | 0 | 1 | 0.089 | 0.0169 | 0.983761 | 3.816861 | 1.35E+ 12 | 797,692.5 | 2.29E+ 18 | 0.000135 |
46,873 | HSD11B1L | ES | 7 | 5.3 | 8 | 0 | 0.9875 | 0.6355 | 0.1149 | 0.608853 | 3.660695 | 39.97543 | 5.548568 | 288.0086 | 0.000252 |
36,205 | FBXL19 | AD | 8.2 | 8.1 | 9 | 0 | 0.9688 | 0.619 | 0.0982 | 0.654726 | −3.66063 | 0.021033 | 0.00266 | 0.166284 | 0.000252 |
9424 | KLHL12 | ES | 12 | 11 | 13 | 0 | 1 | 0.0769 | 0.0148 | 0.979878 | −3.56496 | 2.92E-12 | 1.33E-18 | 6.41E-06 | 0.000364 |
11,318 | CSGALNACT2 | AT | 9 | null | null | 0 | 1 | 0.0611 | 0.0159 | 0.986637 | 3.492296 | 1.03E+ 11 | 67,805.11 | 1.55E+ 17 | 0.000479 |
78,886 | HDAC9 | AP | 6 | null | null | 0 | 0.8062 | 1 | 0.1979 | 0.186725 | 3.459482 | 6.480635 | 2.248003 | 18.68264 | 0.000541 |
55,964 | HAT1 | ES | 3 | 2 | 4 | 0 | 1 | 0.0952 | 0.0188 | 0.964809 | −3.4369 | 4.44E-09 | 7.66E-14 | 0.000257 | 0.000588 |
7584 | PSMD4 | AD | 7.2 | 7.1 | 8 | 0 | 1 | 0.0726 | 0.0137 | 0.066947 | 3.328474 | 8.82E+ 12 | 210,129.5 | 3.70E+ 20 | 0.000873 |
74,575 | CREBRF | AT | 10 | null | null | 0 | 1 | 0.0708 | 0.0157 | 0.984887 | −3.31526 | 4.56E-13 | 2.31E-20 | 9.02E-06 | 0.000916 |
76,557 | DST | AT | 108 | null | null | 0 | 1 | 0.1764 | 0.0191 | 0.985881 | −3.31112 | 7.37E-11 | 7.40E-17 | 7.33E-05 | 0.000929 |
11,956 | CCAR1 | ES | 14 | 13 | 15 | 0 | 1 | 0.1978 | 0.0386 | 0.960246 | 3.293613 | 61,263.4 | 86.78252 | 43,248,395 | 0.000989 |
16,057 | MS4A6A | RI | 9.2 | 9.1 | 9.3 | 0 | 1 | 0.2982 | 0.0523 | 0.339979 | −3.27408 | 0.000744 | 9.98E-06 | 0.055515 | 0.00106 |
254 | MORN1 | AT | 13 | null | null | 0 | 0.975 | 0.6845 | 0.1516 | 0.235858 | 3.262628 | 8.502577 | 2.350391 | 30.75821 | 0.001104 |
30,765 | ZNF280D | AP | 1 | null | null | 0 | 1 | 0.2587 | 0.0575 | 0.869744 | 3.248248 | 382.5969 | 10.57641 | 13,840.28 | 0.001161 |
33,022 | CHTF18 | AD | 10.2 | 10.1 | 11 | 0 | 0.825 | 0.352 | 0.0772 | 0.091989 | −3.24069 | 0.00656 | 0.000314 | 0.13716 | 0.001192 |
30,767 | ZNF280D | AP | 7 | null | null | 0 | 1 | 0.2587 | 0.0576 | 0.130101 | −3.23772 | 0.002682 | 7.44E-05 | 0.096637 | 0.001205 |
68,031 | IGF2BP2 | ES | 11 | 10 | 12 | 0 | 0.75 | 0.7263 | 0.1301 | 0.637773 | 3.218231 | 18.38794 | 3.121825 | 108.3073 | 0.00129 |
22,747 | METTL1 | ES | 4 | 3 | 5 | 0 | 1 | 0.1235 | 0.0248 | 0.966295 | −3.19472 | 1.84E-06 | 5.59E-10 | 0.006076 | 0.0014 |
87,718 | CIZ1 | ES | 6 | 5 | 7 | 0 | 1 | 0.1176 | 0.0222 | 0.976913 | −3.18931 | 2.03E-06 | 6.46E-10 | 0.006397 | 0.001426 |
19,257 | SLC37A2 | ES | 12 | 11 | 13 | 0 | 0.9062 | 0.2732 | 0.0556 | 0.95946 | −3.18231 | 0.002262 | 5.31E-05 | 0.096342 | 0.001461 |
69,370 | HOPX | RI | 4.4:4.5 | 4.3 | 4.6 | 0 | 0.9688 | 0.6206 | 0.13 | 0.645821 | 3.166331 | 9.407206 | 2.349021 | 37.67336 | 0.001544 |
40,976 | NKIRAS2 | AP | 2.1 | null | null | 0 | 1 | 0.2118 | 0.0306 | 0.925296 | −3.16626 | 1.86E-07 | 1.27E-11 | 0.00273 | 0.001544 |
40,977 | NKIRAS2 | AP | 1 | null | null | 0 | 1 | 0.2118 | 0.0306 | 0.074703 | 3.166256 | 5,366,709 | 366.3605 | 7.86E+ 10 | 0.001544 |
2784 | POMGNT1 | RI | 22.2 | 22.1 | 22.3 | 0 | 1 | 0.08 | 0.0128 | 0.983825 | −3.15208 | 3.57E-10 | 4.77E-16 | 0.000267 | 0.001621 |
69,147 | GUF1 | ES | 9 | 8 | 10 | 1 | 0.9187 | 0.431 | 0.0969 | 0.742379 | −3.13883 | 0.036717 | 0.004664 | 0.289067 | 0.001696 |
71,959 | PAIP1 | AP | 2.1 | null | null | 0 | 1 | 0.4933 | 0.0642 | 0.947089 | −3.12525 | 0.00011 | 3.63E-07 | 0.033446 | 0.001777 |
124,660 | FYN | ES | 11 | 10 | 12 | 1 | 0.8188 | 0.7221 | 0.1231 | 0.204459 | −3.09154 | 0.027465 | 0.002812 | 0.268262 | 0.001991 |
11,323 | HNRNPF | AP | 1 | null | null | 0 | 1 | 0.3749 | 0.0566 | 0.109251 | −3.0628 | 0.001469 | 2.26E-05 | 0.095475 | 0.002193 |
36,979 | LRRC29 | AP | 1 | null | null | 0 | 0.975 | 0.9018 | 0.1998 | 0.490236 | −3.05767 | 0.179869 | 0.059894 | 0.540167 | 0.002231 |
69,344 | AASDH | ES | 12 | 11.1 | 13 | 0 | 0.9937 | 0.4611 | 0.0827 | 0.860699 | 3.023399 | 47.21881 | 3.880115 | 574.6262 | 0.0025 |
26,991 | NFATC4 | RI | 12.3 | 12.2 | 12.4 | 0 | 1 | 0.7778 | 0.1157 | 0.749698 | −3.00971 | 0.063154 | 0.010452 | 0.38159 | 0.002615 |
88,691 | ACOT9 | AT | 13.2 | null | null | 0 | 1 | 0.1981 | 0.0369 | 0.057825 | −3.00722 | 0.000126 | 3.60E-07 | 0.0438 | 0.002636 |
88,692 | ACOT9 | AT | 19 | null | null | 0 | 1 | 0.1981 | 0.0369 | 0.942175 | 3.007223 | 7961.978 | 22.83085 | 2,776,643 | 0.002636 |
64,534 | CSPG5 | AD | 4.2 | 4.1 | 5 | 0 | 1 | 0.4724 | 0.0775 | 0.134438 | −3.0036 | 0.003635 | 9.30E-05 | 0.14202 | 0.002668 |
34,421 | LYRM1 | ES | 7 | 2.2 | 8.1 | 0 | 0.9937 | 0.4063 | 0.0723 | 0.844673 | −2.99931 | 0.008166 | 0.000353 | 0.188998 | 0.002706 |
100,544 | PCBP4 | ES | 4.1 | 3 | 5 | 1 | 0.9 | 0.6469 | 0.1241 | 0.469185 | 2.996804 | 11.61581 | 2.33608 | 57.7579 | 0.002728 |
48,957 | GPI | AP | 2.1 | null | null | 0 | 1 | 0.1481 | 0.0255 | 0.955976 | 2.990991 | 2,377,718 | 157.7364 | 3.58E+ 10 | 0.002781 |