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Fig. 5 | BMC Cancer

Fig. 5

From: Exosomal circEIF3K from cancer-associated fibroblast promotes colorectal cancer (CRC) progression via miR-214/PD-L1 axis

Fig. 5

miR-214 downregulated PD-L1 expression in CRC. A PD-L1 expression levels were detected by RT-qPCR in HCT116 cells transiently transfected with NC mimic, miR-214 mimic, NC inhibitor, miR-214 inhibitor. ***p < 0.001. B PD-L1 mRNA levels were detected by RT-qPCR in HCT116 cells expressing sh-NC, sh-circEIF3K-1, sh-circEIF3K-1 plus miR-214 inhibitor. **p < 0.01; ***p < 0.001. C PD-L1 mRNA levels were detected by RT-qPCR in HCT116 cells incubated with exosomes derived from CAFs stably transfected with sh-NC, sh-circEIF3K-1, sh-circEIF3K-2. ***p < 0.001. D TCGA dataset analysis showed PD-L1 levels of CRC tumors (n = 275) and adjacent normal tissues (n = 349). E Working model of hypoxia-induced tumorigenesis of CRC by promoting circEIF3K exosomes secretion from CAFs

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BMC Cancer

ISSN: 1471-2407

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