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Fig. 3 | BMC Cancer

Fig. 3

From: Exosomal circEIF3K from cancer-associated fibroblast promotes colorectal cancer (CRC) progression via miR-214/PD-L1 axis

Fig. 3

circEIF3K modulated CRC progression in animal and patients. A In vivo tumor growth of HCT116 cells treated with sh-NC exosome (sh-NC exo), sh-circEIF3K-1 exosome (sh-circEIF3K-1 exo) were examined in NOD-SCID mice (n = 3). B and C Tumor weights (B) and volumes (C) in Figure 3A were measured. **p < 0.01; ***p < 0.001. D RT-qPCR showed circEIF3K levels of normal colon epithelial cell FHC and CRC cell lines (HCT116 and SW620 cells). ***p < 0.001. E TCGA dataset analysis showed circEIF3K levels of CRC tumors (n = 275) and adjacent normal tissues (n = 349). F Overall survival of CRC patients with low circEIF3K level group (n = 135) and high circEIF3K level group (n = 135). p = 0.017. G Stage plot of CRC patients showed association of circEIF3K levels with stages. p = 0.0126 (stage IV vs stage I)

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BMC Cancer

ISSN: 1471-2407

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