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Table 2 Incidence of nivolumab-induced pneumonitis and UIP diagnosis categories

From: Pre-existing interstitial lung disease is associated with onset of nivolumab-induced pneumonitis in patients with solid tumors: a retrospective analysis

 

Total, n

Any grade, n (%)

≥Grade 3, n (%)

Total

188

22 (11.7)

3 (1.6)

NSCLC

96

14 (14.6)

2 (2.1)

HNC / GC

92

8 (8.7)

1 (1.1)

No fibrosis, all tumor types

148

8 (5.4)

0

No fibrosis, NSCLC

70

4 (5.7)

0

No fibrosis, HNC/GC

78

4 (5.1)

0

Pre-existing ILD, all tumor types

40

14 (35.0)

3 (7.5)

Inconsistent with UIP, all tumor types

28

9 (32.1)

1 (3.6)

Possible UIP/UIP, all tumor types

12

5 (41.7)

2 (16.7)

Pre-existing ILD, NSCLC

26

10 (38.5)

2 (7.7)

Inconsistent with UIP, NSCLC

17

6 (35.3)

1 (5.9)

Possible UIP/UIP, NSCLC

9

4 (44.4)

1 (11.1)

Pre-existing ILD, HNC/GC

14

4 (28.6)

1 (7.1)

Inconsistent with UIP, HNC/GC

11

3 (27.3)

0

Possible UIP / UIP, HNC/GC

3

1 (33.3)

1 (33.3) a

  1. NSCLC non-small cell lung cancer, HNC head and neck cancer, GC gastric cancer, ILD interstitial lung disease, UIP usual interstitial pneumonia; a a case of HNC with possible UIP had grade 5 pneumonitis