From: Possible role of HPV/EBV coinfection in anoikis resistance and development in prostate cancer
Cellular Factors | PCa group (a) vs control (b) | HPV-positive samples (c) vs HPV-negative samples (d) | HPV-positive PCa (e) vs HPV-negative PCa (f) | HPV-positive control (g) vs HPV-negative control (h) | P* | P+ | P$ | P^ |
---|---|---|---|---|---|---|---|---|
NF-κB | a:19.4 ± 7.4 b:9.5 ± 7 | c: 23.5 ± 5.8 d: 13.2 ± 7.9 | e: 24.2 ± 6 f: 17 ± 7 | g: 20 ± 3.9 h: 8 ± 6.05 | < 0.0001 | < 0.0001 | 0.00091.42 | 0.004 |
TNF-α | a:17 ± 7.4 b:11.7 ± 6.7 | c: 21.1 ± 6 d: 12.8 ± 6.6 | e: 22.4 ± 6.4 f: 14.3 ± 6.4 | g: 19.5 ± 3.1 h: 10.6 ± 6.3 | 0.002 | < 0.0001 | < 0.0001 1.56 | 0.03 |
IL-1 | a:13 ± 5.7 b:7.8 ± 5.3 | c: 17.2 ± 4.1 d: 9.1 ± 5.2 | e: 17.3 ± 4.1 f: 10.9 ± 5.1 | g: 16.7 ± 4.2 h: 6.5 ± 4.1 | 0.0002 | < 0.0001 | 0.0003 1.57 | 0.002 |
IL-6 | a:14.4 ± 6 b:8.9 ± 6.6 | c: 18.9 ± 5 d: 10.2 ± 5.8 | e: 18.9 ± 5.2 f: 12.2 ± 5.2 | g: 19 ± 3.9 h: 7.5 ± 5.6 | 0.0004 | < 0.0001 | < 0.0001 2.51 | 0.0004 |
IL-8 | a: 12.62 ± 6.2 b: 5.68 ± 5.1 | c: 17.3 ± 5.1 d:7.6 ± 5.3 | e: 17.7 ± 5.4 f: 10.1 ± 5.09 | g: 15.5 ± 3.1 h: 4.2 ± 3.5 | < 0.0001 | < 0.0001 | 0.004 1.77 | 0.006 |
IL-11 | a: 15.6 ± 8.3 b: 7.1 ± 6.2 | c: 20.52 ± 6.8 d: 9.8 ± 7.4 | e: 21.2 ± 7.2 f: 12.8 ± 7.4 | g: 17 ± 5.08 h: 5.7 ± 4.1 | < 0.0001 | < 0.0001 | 0.02 1.6 | ns |
VEGF | a: 38.64 ± 10.8 b: 13.7 ± 6.9 | c: 48.5 ± 9.5 d: 25.8 ± 12.5 | e: 52.58 ± 3.5 f: 35.8 ± 4.2 | g: 29.5 ± 1.2 h: 11.9 ± 3.7 | < 0.0001 | < 0.0001 | 0.0009 1.46 | 0.005 |
TGF-β | a: 15.2 ± 7.6 b: 7.5 ± 5.1 | c: 19.2 ± 5.7 d: 10.1 ± 7 | e: 19.9 ± 6.1 f: 12.9 ± 7.2 | g: 16 ± 1.6 h: 6.2 ± 4.2 | < 0.0001 | < 0.0001 | 0.02 1.54 | ns |
Rb | a: 9.1 ± 5.7 b: 14.06 ± 6.4 | c: 2.4 ± 1.08 d: 13.8 ± 4.6 | e: 2.6 ± 1.01 f: 12.3 ± 4.1 | g: 1.5 ± 1 h: 15.8 ± 4.6 | 0.0006 | < 0.0001 | < 0.0001 | 0.0003 |
P53 | a: 10.4 ± 6.7 b: 13.9 ± 6.6 | c: 3 ± 1.3 d:14.7 ± 5.2 | e: 3.2 ± 1.35 f: 14.03 ± 5.2 | g: 2 ± 0.8 h: 15.68 ± 5.09 | 0.04 | < 0.0001 | < 0.0001 | 0.002 |
ROS | a: 10.2 ± 9.7 b: 6.09 ± 5.3 | c: 22.3 ± 5.7 d: 3.7 ± 2.7 | e: 23.4 ± 5.5 f: 3.1 ± 2.04 | g: 17 ± 3.6 h: 4.5 ± 3.3 | 0.03 | < 0.0001 | < 0.0001 7.5 | ns |
RNS | a: 11.8 ± 10.3 b: 5.2 ± 5.3 | c: 19.7 ± 8.9 d: 5.9 ± 6.5 | e: 20.2 ± 9.7 f: 7.7 ± 7.8 | g: 17.2 ± 2.6 h: 3.5 ± 2.8 | 0.0002 | < 0.0001 | 0.0004 2.6 | 0.003 |
Survivin | a: 17.8 ± 4.8 b: 9 ± 6.2 | c: 22 ± 3.2 d: 12.1 ± 5.8 | e: 21.9 ± 3.2 f: 15.8 ± 4.1 | g: 22.7 ± 3.5 h: 7.03 ± 3.2 | < 0.0001 | < 0.0001 | 0.0006 | < 0.0001 |
Bcl-2 | a: 12.1 ± 4.2 b: 6.4 ± 4.5 | c: 15.9 ± 3.4 d: 8.1 ± 3.9 | e: 15.6 ± 3.7 f: 10.4 ± 3.4 | g: 17.3 ± 0.8 h: 4.9 ± 1.9 | 0/0001 | < 0.0001 | 0.002 | < 0.0001 |
CD44 | a: 7.9 ± 5.1 b: 4.03 ± 2.4 | c: 7.8 ± 5.1 d: 6.1 ± 4.5 | e:7.9 ± 5.4 f: 8 ± 5.01 | g: 7.5 ± 3.8 h: 3.5 ± 1.8 | 0.0003 | ns | ns | ns |
TWIST | a: 10.2 ± 12.2 b: 6.4 ± 7.2 | c: 25.7 ± 7.5 d: 3.1 ± 2.6 | e: 26.2 ± 8.1 f: 2.4 ± 1.3 | g: 23 ± 1.6 h: 4.03 ± 3.5 | ns | < 0.0001 | < 0.0001 | ns |
E-cad | a: 12.9 ± 8.4 b: 13.5 ± 5.6 | c: 3.4 ± 2.08 d: 16.5 ± 5.6 | e: 3.5 ± 2.2 f:17.5 ± 6.2 | g: 3 ± 0.8 h: 15.07 ± 4.2 | ns | < 0.0001 | < 0.0001 | < 0.0001 |
N-cad | a: 10.7 ± 11.6 b: 5.8 ± 8.4 | c: 25.8 ± 7.6 d:3.2 ± 2.4 | e: 25.7 ± 8.09 f: 3.4 ± 2.1 | g: 26.2 ± 6.2 h: 2.9 ± 2.7 | 0.009 | < 0.0001 | < 0.0001 | 0.004 |
PTPN13 | a: 9.7 ± 5.9 b: 12.9 ± 6.6 | c: 4.4 ± 5.6 d: 13.1 ± 5 | e: 5 ± 6.01 f:12.08 ± 4.4 | g: 2 ± 0.8 h: 14.5 ± 5.5 | 0.03 | < 0.0001 | 0.0007 | 0.004 |
SLUG | a: 2.1 ± 1.8 b: 1.1 ± 2.7 | c: 3.8 ± 1.4 d: 1.01 ± 1.9 | e: 3.9 ± 1.4 f: 1.2 ± 1.3 | g: 3.4 ± 1.2 h: 0.6 ± 2.6 | ns | < 0.0001 | < 0.0001 | Ns |