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Table 1 Demographics of 111 patients with lung adenocarcinoma who underwent surgical resection

From: Histopathologic features from preoperative biopsies to predict spread through air spaces in early-stage lung adenocarcinoma: a retrospective study

variable   All patients (n = 111) Negative for STAS (n = 75) Positive for STAS (n = 36) P value
Age (years)*   59.1 ± 9.1 [35–81] 59.8 ± 9.2 [35–77] 57.6 ± 8.7 [37–81] 0.279
Sex Female 61 39 (52.0%) 22 (61.1%) 0.419
Male 50 36 (48.0%) 14 (38.9%)
Smoking status Never 71 46 (61.3%) 25 (69.4%) 0.527
Former or current 40 29 (38.7%) 11 (30.1%)
Location Upper & middle lobe 61 38 (50.7%) 23 (63.9%) 0.225
Lower lobe 50 37 (49.3%) 13 (36.1%)
Surgery Lobectomy or pneumonectomy 97 61 (81.3%) 36 (100%) 0.004
Sublobar resection 14 14 (18.7%) 0 (0.0%)
Tumor Size (mm)*   22.7 ± 7.9 [8.1–29.5] 22.3 ± 8.4 [8.1–29.5] 23.4 ± 6.6 [8.3–29.1] 0.446
Lymph Node Status N0 89 65 (86.7%) 24 (66.7%) 0.039
N1 14 7 (9.3%) 7 (19.4%)
N2 8 3 (4.0%) 5 (13.9%)
Histologic Subtypes Lepidic 11 11 (14.7%) 0 (0.0%) 0.001
Acinar 55 46 (61.3%) 9 (25.0%)
Papillary 6 2 (2.6%) 4 (11.1%)
Micropapillary 16 5 (6.7%) 11 (30.6%)
Solid 23 11 (14.7%) 12 (33.3%)
Lymphovascular Invasion Absent 91 66 (88.0%) 25 (69.4%) 0.032
Present 20 9 (22.0%) 11 (30.6%)
Visceral Pleural Invasion Absent 101 68 (90.7%) 33 (91.7%) 0.863
Present 10 7 (9.3%) 3 (8.3%)
  1. * Data are mean ± standard deviation. STAS, tumor spread through air spaces