Fig. 2

Differential methylation analysis between tumor samples with high and low gene-associated methylation (GAM) status. a Distribution of mean β-values for the differentially methylated probes (DMPs) between high and low GAM status groups in the TCGA and GSE75067 databases (solid line). The dashed line indicates the local regression line fitted for high or low GAM status groups. The purple and blue line connects the mean β-value for each probe in the high and low GAM status group, respectively. All probes shown here are significantly different between the high and low GAM status groups, based on a linear model for microarray data. b Pie charts and diagrams for visualization of the DMPs annotated with genetic features and CpG features for TCGA (upper panel) and GSE75067 (lower panel) datasets. c Locations of DMPs in ST14 are indicated