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Table 2 Incremental cost-effectiveness ratio under different NTCP-reduction levels and age levels

From: Optimizing oropharyngeal cancer management by using proton beam therapy: trends of cost-effectiveness

NTCP-reductiona

Incremental Cost-effectiveness Ratio ($ / QALY) b

10-year-old

20-year-old

30-year-old

40-year-old

50-year-old

60-year-old

70-year-old

IC / IE

ICER

IC / IE

ICER

IC / IE

ICER

IC / IE

ICER

IC / IE

ICER

IC / IE

ICER

IC / IE

ICER

10%

35,500.8 / 0.16

224,596.4

35,671.1 / 0.15

241,462.0

35,883.7 / 0.13

266,157.7

36,161.8 / 0.12

306,609.3

36,518.4 / 0.10

379,253.1

36,957.9 / 0.07

530,943.8

37,524.3 / 0.04

1,065,357.4

20%

33,001.6 / 0.32

103,402.8

33,342.1 / 0.30

111,778.5

33,767.4 / 0.27

124,042.8

34,323.5 / 0.24

144,131.8

35,036.8 / 0.19

180,208.0

35,915.8 / 0.14

255,540.4

37,048.7 / 0.07

520,939.7

30%

30,502.4 / 0.48

63,116.3

31,013.2 / 0.45

68,662.8

31,651.1 / 0.41

76,784.4

32,485.3 / 0.36

90,087.6

33,555.2 / 0.29

113,977.6

34,873.8 / 0.21

163,863.6

36,573.0 / 0.11

339,614.2

40%

28,003.2 / 0.65

43,054.3

28,684.2 / 0.61

47,186.7

29,534.7 / 0.55

53,237.7

30,647.0 / 0.49

63,149.2

32,073.6 / 0.40

80,948.4

33,831.7 / 0.29

118,115.9

36,097.4 / 0.14

249,058.6

50%

25,504.0 / 0.82

31,080.2

26,355.3 / 0.77

34,364.6

27,418.4 / 0.70

39,173.8

28,808.8 / 0.61

47,051.3

30,592.0 / 0.50

61,197.8

32,789.6 / 0.36

90,737.8

35,621.7 / 0.18

194,808.7

60%

23,004.8 / 0.99

23,148,.8

24,026.3 / 0.93

25,868.1

25,302.1 / 0.85

29,849.9

26,970.5 / 0.74

36,372.2

29,110.4 / 0.61

48,085.0

31,747.5 / 0.44

72,542.9

35,146.1 / 0.22

158,709.6

70%

20,505.6 / 1.17

17,526.1

21,697.4 / 1.09

19,842.1

23,185.8 / 1.00

23,233.4

25,132.3 / 0.87

28,788.3

27,628.7 / 0.71

38,763.8

30,705.5 / 0.52

59,594.3

34,670.4 / 0.26

132,980.9

80%

18,006.4 / 1.35

13,345.5

19,368.4 / 1.26

15,359.2

21,069.5 / 1.15

18,307.9

23,294.0 / 1.01

23,137.8

26,147.1 / 0.82

31,811.5

29,663.4 / 0.59

49,923.4

34,194.8 / 0.30

113,732.3

  1. NTCP normal tissue complication probability, IC incremental cost, IE incremental effectiveness, ICER incremental cost-effectiveness ratio, $ US dollars, QALY quality-adjusted life-year, IMPT intensity-modulated proton radiation therapy, IMRT intensity-modulated photon-radiation therapy
  2. aNTCP-reduction referred to the advantage of IMPT over IMRT in reducing symptomatic dysphagia and xerostomia, and calculated with the equation: NTCP-reduction (%) = [(NTCP after IMRT - NTCP after IMPT) / NTCP after IMRT] *100%
  3. bThe outcome measure of cost-effectiveness is ICER (ICER = IC [$] / IE [QALY])
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BMC Cancer

ISSN: 1471-2407

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