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Table 2 Immunohistochemistry results of the CMA

From: Cancer cell line microarray as a novel screening method for identification of radioresistance biomarkers in head and neck squamous cell carcinoma

Cell line

Primary site

AUC

p53 wt DNA

p53 mutation

Immunohistochemistry

p53

LIMA1

EGFR

NDFIP1

Oct4

CIP2A

UT-SCC-2

floor of mouth

1.8 ± 0.2

no

c.275 CCC > CAT

mutated

1

3

0

1

2

UT-SCC-5

tongue

2.3 ± 0.3

no

c.151 CCC > CAT

mutated

2

3

1

1

1

UT-SCC-7

temporal skin

2.0 ± 0.2

yes

c.266 GGA > GAA

mutated

1

3

1

1

3

UT-SCC-8

supraglottic

1.9 ± 0.1

no

c.255 ATC > TTC

mutated

1

3

1

1

2

UT-SCC-9

glottic

1.4 ± 0.1

no

total deletion

absent

1

2

0

0

2

UT-SCC-14

tongue

1.7 ± 0.3

yes

deletion, frameshift

mutated

1

3

0

1

2

UT-SCC-16A

tongue

1.8 ± 0.1

 

c.110 CGT > TGT / c.232 ATC > AAC

mutated

1

2

0

0

1

UT-SCC-17

supraglottic

1.8. ± 0.1

 

c.110 CGT > CTT / c.257 CTG > CAG

mutated

2

3

1

1

3

UT-SCC-19A

glottic

1.7 ± 0.1

no

c.285 GAG>AAG

mutated

2

3

0

0

3

UT-SCC-20A

floor of mouth

2.1 ± 0.2

yes

c.248 CGG > TGG

mutated

2

2

1

1

2

UT-SCC-24A

tongue

2.6 ± 0.3

yes

47 bp insertion, frameshift

absent

2

3

1

1

3

UT-SCC-25

tongue

 

no

c.248 CGG > TGG

mutated

2

3

1

1

2

UT-SCC-30

tongue

2.0 ± 0.1

no

c.282 CGG > CCG

mutated

1

2

0

1

1

UT-SCC-32

tongue

1.7 ± 0.3

no

c.266 GGA > GAA

mutated

1

3

1

0

1

UT-SCC-34

supraglottic

2.0 ± 0.1

yes

total deletion

absent

1

3

1

1

1

UT-SCC-36

floor of mouth

2.2 ± 0.2

no

c.244 GGC > AGC

mutated

1

2

1

1

3

UT-SCC-45

floor of mouth

2.0 ± 0.1

  

wt

1

3

0

1

1

UT-SCC-46A

retromolar gingiva

1.6 ± 0.1

  

wt

1

1

0

0

1

UT-SCC-47

floor of mouth

2.0 ± 0.2

  

absent

2

2

1

1

3

UT-SCC-50

glottic

   

wt

2

3

1

1

2

UT-SCC-60B

tonsil

2.2 ± 0.3

  

absent

2

2

0

1

2

UT-SCC-72

mandibular gingiva

2.8 ± 0.2

  

absent

2

3

1

1

2

UT-SCC-74A

tongue

   

wt

1

3

0

1

2

UT-SCC-76A

tongue

2.5 ± 0.2

  

mutated

1

3

0

0

1

UT-SCC-79A

parotid

2.4 ± 0.2

yes

deletion, frameshift

wt

2

3

1

1

1

UT-SCC-79B

parotid

2.5 ± 0.1

yes

deletion, frameshift

wt

2

2

1

1

1