Table 2 Results summary
Assay | Cell line | Genetic modification / Treatment | Results compared to control |
|---|---|---|---|
Proliferation | 786-0 WT | PT2385 | = |
Clonogenic assay | 786-0 WT | PT2385 | = |
RCC4 VHL | VHL overexpression | + | |
RCC4 WT | PT2385 | = | |
Migration | 786-0 WT | PT2385 | = |
786-0 WT | siHIF2α | = | |
RCC4 WT | PT2385 | + | |
RCC4 VHL | VHL overexpression | + | |
Invasion | 786-0 WT | PT2385 | - |
RCC4 VHL | VHL overexpression | = | |
RCC4 WT | PT2385 | = | |
Sensitivity to statins | 786-0 WT | siHIF2α | + |
Sensitivity to terbinafine | 786-0 WT | siHIF2α | - |